Human prefrontal cortex gene regulatory dynamics from gestation to ...

Common dysregulation network in the human prefrontal cortex ...

We investigated global disruptions in the co‐regulation of genes in two neurodegenerative diseases, late‐onset Alzheimer's disease (AD) and Huntington's ...

Resultados de la búsqueda - CNIC

Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution. Cell (2022) 185:4428-+. Link to the full text in ...

Accelerated Recruitment of New Brain Development Genes into the ...

Remarkably, we also identified a number of human-specific genes which are expressed in the prefrontal cortex, which is implicated in complex cognitive behaviors ...

Study Reveals How Gene Regulation Helps Determine Brain ...

It is centrally involved in the patterned development of the human brain. Irregularities in chromatin dynamics likely contribute to ...

Epigenetic regulation of human-specific gene expression in the ...

Changes in gene expression levels during brain development are thought to have played an important role in the evolution of human cognition.

Saskia Freytag - Research Data Australia

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Genetics of human brain development

Its derivative retinoic acid — an evolutionarily differentially regulated signalling molecule that presents an anterior-to-posterior, prefrontal cortex-enriched ...

Spatio-temporal transcriptome of the human brain

mid-fetal frontal cortex, with the highest expression in OFC and the ... Temporal dynamics and genetic control of transcription in the human prefrontal cortex.

Single-Nuclei RNA Sequencing of 5 Regions of the Human Prenatal ...

We found evidence for a distinct contribution of prenatal neuronal development to genetic risk for schizophrenia, involving specific populations of developing ...

UCLA's Revolutionary DNA Mapping Reveals Secrets of Human ...

Figuring out how these two regulatory elements act on genes that affect development is a critical step to understanding how ...

Gene regulatory mechanisms underlying sex differences in brain ...

Extraordinary neoteny of synaptic spines in the human prefrontal cortex. ... Spatial and temporal mapping of de novo mutations in schizophrenia to ...

Scientists Create First Map of DNA Modification in Developing ...

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development.

Projects - HCA Data Explorer

Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution ... Human cerebral organoids recapitulate gene expression ...

Mapping DNA Modification in the Developing Human Brain

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development.

Expression quantitative trait loci in the developing human brain and ...

Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, ...

BrainDevo: Spatio-Temporal Gene Regulation Repository of Brain ...

We have developed and deployed a data source to identify transcriptional and post-transcriptional regulators in 16 brain regions during human ...

Identification of the Molecular Events Involved in the Development of ...

Altered profile of gene expression drives many cellular and molecular events required for development. Here, the molecular events during ...

Single-cell RNA-sequencing of mammalian brain development - OUCI

Trevino, Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution, Cell, № 184, с. 5053 https://doi.org ...

Coordinated Gene Expression of Neuroinflammatory and Cell ...

We used a large-scale microarray dataset from human prefrontal cortex, BrainCloud, to quantify age changes over the lifespan, divided into ...

Molecular and cellular dynamics of the developing human neocortex ...

The development of the human neocortex is a highly dynamic process and involves complex cellular trajectories controlled by cell-type-specific gene regulation.