Predicting the genetic risk of glaucoma

Renewed focus on predicting glaucoma risk

He says the study found individuals with a large number of the genetic markers had an almost six-fold increased risk of developing glaucoma ...

How genome-wide association studies transform care for patients at ...

While discovering genes contributing to adult-onset glaucoma has been historically difficult, advancements in genome-wide association studies (GWAS) over the ...

Multitrait analysis of glaucoma identifies new risk loci and enables ...

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Craig JE 1 ...

Glaucoma Risk Factor Linked to More Than 100 Genetic Loci in ...

Through a meta-analysis of nearly 140000 people, an international team of researchers tied 112 loci to increased intraocular pressure, ...

Glaucoma and Genetics: Is It Inherited? - Healthline

In some cases, glaucoma has a genetic component. Having a parent or other close relative with glaucoma can also increase your risk of developing it.

Polygenic Risk Scores and Genetically Complex Eye Disease

The success of genome-wide association studies (GWASs) in uncovering genetic variants associated with complex eye diseases has paved the way ...

Predictive genetic testing experience for myocilin primary open ...

Predictive genetic testing of relatives of known myocilin (MYOC) gene mutation carriers is an appropriate strategy to identify individuals at risk for glaucoma.

Molecular Genetics of Glaucoma: Subtype and Ethnicity ... - MDPI

Genes associated with elevated IOP or POAG risk include: ABCA1, AFAP1, ARHGEF12, ATXN2, CAV1, CDKN2B-AS1, FOXC1, GAS7, GMDS, SIX1/SIX6, TMCO1, and TXNRD2.

Attitudes Towards Polygenic Risk Testing in Individuals with Glaucoma

These individuals may have expected glaucoma to develop, regardless of the potential calculated genetic risk, based on a strong family history ...

Novel ancestry-specific primary open-angle glaucoma loci and ...

3 locus, with expression effect on CDKN2A/B. Our results suggest that some POAG risk variants may be ancestry specific, sex specific, or both, and support the ...

International Team Identifies 127 Glaucoma Genes in Largest Study ...

The risk loci identified include genes that are highly expressed in relevant eye tissues, nerves, arteries and other tissues related to glaucoma ...

Genetic markers for intraocular pressure may improve risk prediction ...

Glaucoma is the leading cause of irreversible blindness in the world. Raised intraocular pressure (IOP) is the most important modifiable risk ...

Genetic risk of glaucoma is associated with vascular and retinal ...

Higher genetic risk for glaucoma was associated with both vascular wedge defects and RNFL defects (p < 0.001 and p = 0.020, respectively). A ...

With retinal images and genetic data, researchers predict ...

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary ...

Polygenic risk score-based phenome-wide association for glaucoma ...

Genetic predisposition to POAG has been previously associated with the severity and predictive aspects of the disease. Individuals in the top 5% ...

Genetic prediction models for primary open-angle glaucoma - HKMJ |

4. This study confirmed the association of variant rs33912345 in the SIX6 gene with POAG, and identified a new variant rs12436579 for the disease in Chinese. 5.

UTHSC's Yousefi Receives $2.2 Million To Develop AI Aimed at ...

... Predicting Glaucoma Risk. Written by Lee Ferguson ... genetic factors alone are insufficient to predict the risk of glaucoma accurately.

Unique gene variants tied to glaucoma found in Black patients

Having a family history of glaucoma is a major risk factor for the disease, meaning genetics play an influential role. Previous studies ...

High genetic risk associated with rapid visual field worsening in ...

Individuals with a high polygenic risk were more likely to experience rapid structural and functional progression in early-stage glaucoma, ...

Glaucoma Genetic Risk Scores in the Million Veteran Program

POAG–associated loci individually confer incremental risk. Genetic risk score(s) (GRS) could enable POAG risk stratification. Despite significantly higher POAG ...