Relationship Between Dihydropyrimidine Dehydrogenase Gene ...

Strong Association of a Common Dihydropyrimidine ... - PLOS

Cancer patients carrying mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have a high risk to experience severe drug-adverse effects following ...

DPYD Genotyping Recommendations

DPYD is a polymorphic gene with approximately 1600 variants described in Genome Aggregation Database version 4.0.0 to date; however, most of ...

Germline cis variant determines epigenetic regulation of the anti ...

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Ting Zhang ...

272P Correlation of dihydropyrimidine dehydrogenase gene ...

We found that diarrhea and mucositis were related to the DPD gene mutation more than anemia, neutropenia and thrombocytopenia.

Mutational spectrum of dihydropyrimidine dehydrogenase gene ...

Dihydropyrimidine dehydrogenase enzyme (DPD) deficiency is a pharmacogenetic syndrome leading to severe side-effects in patients receiving therapies ...

Very Important Pharmacogene: DPYD - PharmGKB

A DPYD variant (Y186C) in individuals of african ancestry is associated with reduced DPD enzyme activity. Clinical pharmacology and therapeutics. 2013. Offer ...

Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding ...

Alterations in dihydropyrimidine dehydrogenase gene (DPYD) coding for the key enzyme (DPD) of fluoropyrimidines (FPs) catabolism contribute to the ...

Dihydropyrimidine Dehydrogenase Gene (DPYD) Polymorphism

We present the analysis of DPYD genotyping in untreated Caucasian patients (control group) and Caucasian patients with 5-FU/CAP-related grade 3/4 toxicities ( ...

Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in ...

Dihydropyrimidine dehydrogenase (DPD) is an enzyme (EC 1.3.1.2) encoded by DPYD gene. DPD is the rate-limiting enzyme for catabolism of uracil, thymine and ...

Mutational Analysis of the Human Dihydropyrimidine ...

Mutations in the DPYD gene, which encodes dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in the catabolism of pyrimidines, are responsible ...

Association and prediction of severe 5-fluorouracil toxicity with ...

The aim of the present study was to evaluate the association and prediction of dihydropyrimidine dehydrogenase gene (DPYD) polymorphisms and ...

Impact of DPYD, DPYS, and UPB1 gene variations on severe drug ...

To investigate the association between these genetic variations and FP-related high toxicity in a Japanese popula- tion, we obtained blood ...

Correlation between dihydropyrimidine dehydrogenase and efficacy ...

Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the catabolism of 5-FU, and DPD enzymatic activities are usually varied dramatically from ...

Prognostic Impact of Dihydropyrimidine Dehydrogenase Germline ...

Among patients carrying a variant in the DPYD gene, the most frequent adverse reactions were gastrointestinal manifestations, such as ...

Characterization of Reference Materials for DPYD

The DPYD gene encodes dihydropyrimidine dehydrogenase (DPD), which is involved in the catalysis of uracil and thymine, ...

SAFETY MATTERS - Annals of Research in Oncology

highlighted a strong correlation between DPYD*2A and c.2846A ... Influ- ence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the.

Pharmacogenetic and clinical aspects of dihydropyrimidine ...

Mutations in DPYD (the human dihydropyrimidine dehydrogenase gene) of patients suffering from severe 5- uorouracil- ... Relationship between 5-fluorouracil ...

Improving the utility of dihydropyrimidine dehydrogenase genetic ...

A typical example of this is dihydropyrimidine dehydrogenase (DPD) genetic testing. Dihydropyrimidine dehydrogenase is an enzyme that breaks down the anticancer ...

A DPYD Variant (Y186C) Specific to Individuals of African Descent ...

V72A variant in genetic association studies with oxaliplatin toxic effect or response. ... Clinical relevance of different dihydropyrimidine dehydrogenase gene ...

Dihydropyrimidine Dehydrogenase Deficiency via the DPYD Gene

Dihydropyrimidine dehydrogenase (DPD) deficiency (also termed hereditary thymine-uraciluria; OMIM# 274270) is an inherited error in pyrimidine metabolism ...