Review of Pseudobulbar Affect Including a Novel and Potential ...

The epidemiology and pathophysiology of pseudobulbar affect and ...

of PBA, a comprehensive literature review of pediatric and adult publications ... Petroclival meningioma presenting with pathological laughter: report of a case ...

Radiological correlates of pseudobulbar affect

In line with the two most common pathophysiological conceptualisation of PBA, the. “corticobulbar bulbar hypothesis” and “cerebellar hypothesis” ...

Laughter, crying and sadness in ALS

PBA was associated with bulbar onset and dysfunction, upper motor neuron dysfunction, cognitive impairment, depression and lower quality of life. A ...

An Exploration of Pseudobulbar Affect - Temple University

Key brain structures involved in emotional regu- lation include the hippocampus, which aids in the processing of emotional memories [10], and the frontal cortex ...

021879Orig1s000 - accessdata.fda.gov

Following submission of the NDA for use of DM 30 mg/Q 30 mg for the treatment of PBA, the FDA suggested that a combination containing a lower ...

Pseudobulbar Affect in Parkinsonian Disorders: A Review. - Abstract

PBA is a socially and emotionally debilitating symptom that has been estimated to affect 3.6% to 42.5% of the population with Parkinson's disease. While ...

Pseudobulbar Affect: An Often-Overlooked Condition - Geron

“The symptoms of PBA can be severe, with persistent, unremitting episodes having a sudden or unpredictable onset,” explained George T. Grossberg ...

Pseudobulbar affect: When patients laugh or cry, but don't know why ...

Symptoms are involuntary, uncontrolled, and exaggerated or incongruent with current mood. Episodes, lasting a few seconds to several minutes, may be unprovoked ...

Neuronal Dysregulation in Stroke-Associated Pseudobulbar Affect ...

PBA is now understood to be a disinhibition syndrome in which specific pathways involving serotonin and glutamate are disrupted or modulated causing reduced ...

Pseudobulbar Affect: How to Ensure Quality PBA Treatment

The emotions that people with PBA most often express are involuntary laughing or crying. Despite the obvious symptoms, PBA is notoriously hard to diagnose.

Pseudobulbar affect: prevalence and management - ScienceOpen

A recent novel attempt to estimate the prevalence of PBA in the USA across six neurological disorders utilized an online survey of patients with ALS,. MS ...

What Is Pseudobulbar Affect? Symptoms, Causes, Diagnosis ...

People who have pseudobulbar affect have sudden, frequent, and uncontrollable episodes of laughing or crying. PBA occurs along with other brain disorders, ...

Enhancing Approaches to the Identification and Management of ...

Pseudobulbar affect (PBA) is a socially debilitating condition that primarily affects people with neurologic diseases, such as Alzheimer's disease or multiple ...

Pseudobulbar Affect in Patients with Multiple Sclerosis - Pure

Possible reasons for the observed variability in the prevalence data include heterogeneity of the diagnostic methodologies and common presence ...

Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA ...

PBA symptoms were also found to be an important reason for becoming housebound (CNS-LS); laughing; or suffering other adverse life situations. An Center ...

A Novel Research Tool to Assess the Prevalence of Pseudobulbar ...

However, PBA symptoms were associated with greater impact of the neurological condition on QOL and greater incidence of antidepressant/antipsychotic use. These ...

Dextromethorphan/quinidine for pseudobulbar affect

treatment of pseudobulbar affect (PBA) associated with chronic neurological disorders ... Review of pseudobulbar affect including a novel and potential therapy. J ...

Marketing a Disease, and Also a Drug to Treat It - The New York Times

It is because the condition mimics damage to the brain stem, or bulb, that the company decided to call it pseudobulbar affect. Advertisement.

Pseudobulbar Affect or Depression in Dementia?

Often, patients are misdiagnosed as having depressed mood. This is not surprising as 30%–35% of patients with PBA are depressed. Duration and type of symptoms ...

Safety | NUEDEXTA®| Pseudobulbar Affect Treatment| HCP Site

PBA is often comorbid with depression and other mood disorders, but PBA is a distinct condition that should be treated separately. ... Patients with PBA may ...