Carboplatin dosing

Pharmacokinetics of high-dose carboplatin in children undergoing ...

Pharmacokinetic (PK) analysis of high-dose carboplatin was performed in pediatric solid tumor patients undergoing high-dose chemotherapy (HDCT) and autologous ...

Carboplatin: Drug information - UpToDate Free

Dosing: Adult. Note: Doses for adults are commonly calculated by the Target AUC using the Calvert formula, where Total dose (mg) = Target AUC x (GFR + 25).

Carboplatin dosing: gender bias and inaccurate estimates of ...

There is increasing support for the application of dosing formulae for carboplatin based on renal function. [1,2]. Carboplatin doses can be calculated from ...

Investigating current practices in renal function measurement and ...

Renal function-based carboplatin dosing is a well-accepted practice in pediatric oncology, having been shown to provide more consistent drug exposures than ...

Generation of evidence-based carboplatin dosing guidelines for ...

Generation of evidence-based carboplatin dosing guidelines for neonates and infants · Downloads · Licence · Abstract · Publication metadata · Altmetrics.

Multi-Institutional Validation Study of Carboplatin Dosing Formula ...

Abstract. Creatinine clearance (Ccr) is widely used as a practical substitute for glomerular filtration rate (GFR) in the Calvert formula: carboplatin dose (mg) ...

Carboplatin Area Under the Curve dosing in pediatric patients

El objetivo de este estudio es comparar las dosis de carboplatino calculadas empleando la TFG medida con Cr51-EDTA y la estimada con la fórmula de Schwartz en ...

Standardization of Chemotherapy and Individual Dosing of Platinum ...

Abstract. Platinum compounds represent a pharmacological class essential for the treatment of certain types of cancer. Cisplatin, carboplatin ...

Weekly vs. Every-3-Week Paclitaxel and Carboplatin for Ovarian ...

We aimed to determine whether in the primary treatment of ovarian cancer, dose-dense weekly paclitaxel combined with carboplatin would prolong ...

Comparative Study of Carboplatin Dosing in Lung Cancer Patients ...

In this study, the doses of carboplatin calculated by the Calvert formula based on estimated GFRs with various GFR equations were compared with the doses of ...

Optimizing carboplatin dosing by an improved prediction of ...

Abstract. Aims: Carboplatin is generally dosed based on a modified Calvert formula, in which the Cockcroft–Gault-based creatinine clearance (CRCL) is used as ...

Current dilemmas in carboplatin dosing. - PharmGKB

Current dilemmas in carboplatin dosing. ... Clinical advances in hematology & oncology : H&O. 2011. Overview · Prescribing ...

Radiotherapy versus single-dose carboplatin in adjuvant treatment ...

From our study, one injection of carboplatin at a dose of AUC×7 has shown, with a median of 4 years' follow-up, to be an effective adjuvant treatment for stage ...

Difficulties in carboplatin dosage due to different methods of serum ...

Using these creatinine values for Ccr estimation through C&G formula results in significant higher clearance values than with a Jaffé based serum creatinine ...

Investigating current practices in renal function measurement and ...

Renal function-based carboplatin dosing is a well-accepted practice in pediatric oncology. However, the accuracy of this approach is only as ...

Generation of evidence-based carboplatin dosing guidelines for ...

Optimised daily doses for patients ≤10 kg were 6 mg/kg and 9 mg/kg for cumulative carboplatin target exposures of 5.2 and 7.8 mg/ml.min, ...

Carboplatin Dosing in Real Life: Beyond Estimating Glomerular ...

In routine oncologic practice, the carboplatin dosage is usually estimated based on AUC‑based dosing since carboplatin clearance closely matches ...

New Model for Estimating Glomerular Filtration Rate and Accurately ...

... carboplatin dosing compared with other published models in cancer patients. Their findings were reported in the Journal of Clinical Oncology ...

Improving Carboplatin Dosing Based on Estimated GFR

Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989; 7: 1748-1756

Carboplatin Dosing in Children: Calculation by Different Formulae

Abstract. Background: Carboplatin dosing in children is based on renal function and there exists a wealth of formulae available for ...