Major study links two new genetic variants to breast cancer

Everyone has BRCA1 and BRCA2 genes. BRCA stands for BReast CAncer gene. They are important genes that stop the cells in our body from growing and dividing out ...

187 new genetic variants linked to prostate cancer found in largest ...

The study, published in Nature Genetics, builds on 2021 research documented in the same journal that found 269 genetic variants correlating with ...

First genetic link discovered to difficult-to-diagnose breast cancer ...

Scientists have identified the first genetic variant specifically associated with the risk of a difficult-to-diagnose cancer subtype, ...

Genetic Variants Associated With Cancer Therapy–Induced ...

We hypothesized that rare variants in cardiomyopathy genes contribute to CCM. Methods: We studied 213 patients with CCM from 3 cohorts: ...

breast cancer - GWAS Catalog

... Study of Genetic Variants Related to Anthracycline-Induced Cardiotoxicity in Early Breast Cancer. ... study in breast cancer identifies two new risk ...

New Study Shows Many People Don't Know They Carry Genes For ...

Genetic factors play a role in as much as 10% of all cases of breast and ovarian cancer. And yet, according to a new study published in the ...

Genetics of breast cancer: Applications to the Mexican population

Breast cancer research has yielded several important results including the strong susceptibility genes, BRCA1 and BRCA2 and more recently 19 genes and genetic ...

Breast cancer and inherited susceptibility

Where one parent has a BRCA1, BRCA2 or PALB2 gene variant, in every pregnancy each of their children has a: 1 in 2 (50%) chance of inheriting the pathogenic ...

Aggregation tests identify new gene associations with breast cancer ...

Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple ...

Genetic Risk of Second Primary Cancer in Breast Cancer Survivors

This multiethnic study links germline pathogenic variants in BRCA1, BRCA2, and ERCC2 to the development of second primary cancer in breast cancer.

Associations Between Cancer Predisposition Testing Panel Genes ...

Findings In a case-control study of 65 057 patients with breast cancer, inherited pathogenic variants in PALB2 were associated with high risks ...

Breast Cancer Risk Factors: Inherited Gene Mutations

Everyone has BRCA1 and BRCA2 (BRCA1/2) genes. Some people have an inherited mutation in one or both of these genes that increases the risk of breast cancer.

Genetics of Breast and Gynecologic Cancers (PDQ®)

In both studies, significant associations were reported between eight genes and breast cancer development (BRCA1, BRCA2, PALB2, BARD1 ...

Test Results for BRCA1, BRCA2, and Other Gene Mutations

There are multiple genetic mutations known to increase the risk of breast cancer. Two of the most well-known genes associated with breast cancer ...

Gender-Specific Genetic Predisposition to Breast Cancer - MDPI

The largest available prospective study showed that women with germline BRCA1 PVs have a cumulative BC risk to age 80 years of 69% [45], whereas recent ...

Breast cancer risk variants identified for women of African ancestry

A study led by researchers from Vanderbilt-Ingram Cancer Center sheds light on some of the genetic variants that make breast cancer more deadly for women of ...

Influence of family history on penetrance of hereditary cancers in a ...

Women with a pathogenic BRCA1 or BRCA2 variant had an increased risk of breast cancer that was higher in those with a first-degree family ...

1000s of breast cancer gene variants engineered, analyzed

A new scientific analysis of nearly 4,000 mutations deliberately engineered into the BRCA1 gene will immediately benefit people undergoing ...

Beyond BRCA and breast cancer risk

Many people know that certain variants (or mutations) in the DNA-repair genes BRCA1 and BRCA2 can drive breast and ovarian cancers.

the genetic link between lynch syndrome and breast cancer

This study that evaluates breast cancer and Lynch syndrome risk genes shows women with mutations in MSH6 and PMS2 have an increased risk for ...