Nature medicine's 11 clinical trials that will shape medicine in 2023.

Adjuvant nivolumab in resected stage IIB/C melanoma - Nature

Data from the phase 3 KEYNOTE-716 trial led to US Food and Drug Administration and European Medicines Agency approval of adjuvant pembrolizumab ...

Clinical trials are becoming more complex: a machine learning ...

The past decade has seen substantial innovation in clinical trials, including new trial formats, endpoints, and others.

Dupilumab in patients with prurigo nodularis - Nature

Scientific and medical researchers may request access to study documents (including the clinical study report, study protocol with any ...

Next-generation CRISPR-based gene-editing therapies ... - Nature

There are at least nine base-editing therapies currently in clinical trials, says Liu. At the American Heart Association conference in November ...

Patient stratification for determining optimal second-line and third ...

TriMaster Study group. Show authors. Nature Medicine volume 29, pages 376–383 (2023)Cite this article. 9527 Accesses. 32 Citations. 49 Altmetric.

Precision medicine: affording the successes of science - Nature

This figure is lower for oncology at 6.7%. In stage 3, new drugs may become a reimbursed standard of care after policymakers review for clinical ...

Atezolizumab plus anthracycline-based chemotherapy in metastatic ...

The randomized, placebo-controlled ALICE trial (NCT03164993) evaluated the addition of atezolizumab (anti-PD-L1) to immune-stimulating chemotherapy in mTNBC.

Progress and prospects of mRNA-based drugs in pre-clinical and ...

... II initiated in April 2020), to transition from development to clinical trials. ... figure should be viewed dialectically. PS protein ...

Early treatment of COVID-19 with anakinra guided by soluble ...

The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety of anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at ...

Priorities for cancer research in low- and middle-income countries

Cancer clinical trials of investigational new drugs remain ... I agree my information will be processed in accordance with the Nature and Springer ...

Two-year effects of semaglutide in adults with overweight or obesity

... Treatment Effect in People with Obesity (STEP) clinical trial program. In the STEP 1 and 3 trials in participants without type 2 diabetes ...

Knowledge, attitudes, and concerns about psilocybin and MDMA as ...

Psilocybin and MDMA may become approved medicines in the coming decade. This study assessed knowledge and attitudes regarding PAT among 879 U.S. ...

Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 ...

Nature Medicine volume 29, pages 2902–2908 (2023)Cite this article ... II clinical trials. Antivir. Ther. 7, 53–65 (2002). Article CAS ...

Diagnosis of Alzheimer's disease using plasma biomarkers adjusted ...

Negative p-tau217 results could rule out amyloid-β pathology in individuals with non-AD dementia syndromes (negative predictive value between 90 ...

Impact of L-carnitine supplementation on gastric emptying ... - Nature

... trial [ClinicalTrials.gov Identifier NCT06255873 (13/02/2024)]. The CONSORTreporting guidelines was used to present the clinical trial data.

Mapping global public perspectives on mRNA vaccines and ... - Nature

... studies and clinical trials. This emerging treatment holds great ... 2023, and reaching a low of 672 tweets on September 11, 2022.

Pathomic and bioinformatics analysis of clinical-pathological and ...

Traditional prognostic indicators like tumor stage and invasion depth are insufficient for precision medicine's needs. Pancreatic cancer ...

Effect of genetically predicted sclerostin on cardiovascular ... - Nature

More recently, sclerostin inhibition has been clinically investigated as a potential therapeutic target for osteoporosis, and two medicines ( ...

Antimicrobial stewardship implementation in primary and secondary ...

Indian Council of Medical research (ICMR) also published generic guidelines on antimicrobial stewardship program (AMSP) for India. The purpose ...

The deleterious effects of CDK4/6 inhibition on renal recovery post ...

Acute kidney injury (AKI) is a common clinical problem, and patients who survive AKI have a high risk of chronic kidney disease (CKD).