[PDF] Common Genetic Determinants of Intraocular Pressure and ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

In conclusion, this genome-wide association study in 8 independent Caucasian cohorts identified rs11656696 in GAS7 at chromosome 17p13.1 and ...

Common Genetic Determinants of Intraocular Pressure and ... - PLOS

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

[PDF] Common Genetic Determinants of Intraocular Pressure and ...

GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina, and both genes ...

Common genetic determinants of intraocular pressure and primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

(PDF) Common Genetic Determinants of Intraocular Pressure and ...

However, it has proven difficult to identify the specific genes involved. Intraocular pressure (IOP) is the major risk factor for glaucoma and the only target ...

Common genetic determinants of intraocular pressure and primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

Common genetic determinants of intraocular pressure and primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic ...

(PDF) Common genetic determinants of intraocular pressure and ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

Genetic Determinants of Intraocular Pressure | Request PDF

Intraocular pressure (IOP) is the cardinal and only modifiable risk factor for glaucoma, the leading cause of irreparable blindness worldwide.

Genetic Determinants of Intraocular Pressure - UCL Discovery

Abstract. Intraocular pressure (IOP) is the cardinal and only modifiable risk factor for glaucoma, the leading cause of irreparable blindness worldwide.

A large multi-ethnic genome-wide association study identifies novel ...

Our report of 40 novel loci associated with IOP substantially increased the proportion of variance in IOP explained by specific genetic factors.

Common and Rare Genetic Risk Factors for Glaucoma

The characterization of genes responsible for glaucoma is the critical first step toward the development of gene-based diagnostic and screening tests, ...

Primary open angle glaucoma genetics: The common variants and ...

The well recognised risk factors for POAG include higher age, high IOP, decreased central corneal thickness (CCT), African descent, high myopia ...

10Years of GWAS in intraocular pressure - Frontiers

Identifying genetic factors that contribute to IOP aid in uncovering the biological mechanisms regulating this trait (Ojha et al., 2013; Xu et ...

Genome-wide analysis identified 17 new loci influencing intraocular ...

Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new ...

Towards modifying the genetic predisposition for glaucoma: An ...

Well-established non-modifiable risk factors for POAG include older age, non-White ethnicity, and family history of glaucoma (Stein et al., 2021) – with the ...

Replication of a Glaucoma Candidate Gene on 5q22.1 for ... - IOVS

The IOP levels used in this study were of cross-sectional measurements that include intraindividual variation as well as measurement errors. However, it is ...

Genetic correlations between intraocular pressure, blood ... - Nature

We formed genome-wide significant variant panels for IOP and diastolic BP and found a strong relation with POAG (odds ratio and 95% confidence ...