[PDF] Development of novel agents based on nitric oxide for the ...

Development of novel agents based on nitric oxide for the control of ...

Abstract. Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) repre- sent a novel class of compounds that hold promise as agents for the ...

The mechanism of action of NO-NSAIDs involves the modulation of several critical cellular signaling pathways, whereas the induction of a state of oxidative ...

Development of novel agents based on nitric oxide for the control of ...

Development of novel agents based on nitric oxide for the control of colon cancer. ... Download. The PDF file you selected should load here if your Web browser ...

Development of novel nitric oxide production inhibitors based on the ...

Nitric oxide (NO), the smallest signaling molecule known, can be excessively produced by overexpressed inducible nitric oxide synthase ...

Development of novel nitric oxide production inhibitors based on the ...

Request PDF | Development of novel nitric oxide production inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold | Nitric oxide (NO), ...

Development of a novel nitric oxide (NO) production inhibitor with ...

Research paper. Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation.

Development of a novel nitric oxide (NO) production inhibitor with ...

Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation ... Eur J Med Chem. 2020 ...

Discovery of a novel inhibitor of nitric oxide production with potential ...

... development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural ...

Recent developments in nitric oxide donor drugs - PMC

Importantly, these novel compounds do not produce tolerance with long-term continuous use and remain fully activity in nitrate-tolerant blood vessels (Miller et ...

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO) - MDPI

In a proof-of-concept study, we successfully incorporated nitrate ester groups onto two previously studied potent antisickling aromatic aldehydes.

(PDF) Application of nitric oxide in drug discovery and development

Introduction: It is becoming increasingly clear that many diseases are characterized or associated with perturbations in nitric oxide (NO) ...

Nitroglycerin and Nitric Oxide — A Rondo of Themes in ...

The development of a wide range of therapeutics based on the nitric oxide ... novel antianginal agents that enhance cGMP-modulated ...

Nitric oxide - a novel antimicrobial agent - SpringerLink

We now know that NO is synthesised continually in vascular endothelium and the brain, and that many disease processes, particularly those involving infection ...

Nitric oxide donors and cardiovascular agents modulating the ...

Several NO donors have been used in clinical settings for decades (eg, nitroglycerin and nitroprusside). However, the growth of interest in the ...

Nitric Oxide Generating/Releasing Materials - Taylor & Francis Online

Sodium nitroprusside (SNP) is another NO-based drug that is in use for vasodilation in emergency setting to treat acute hypertension [Citation9] ...

Novel Agents Targeting Nitric Oxide | Bentham Science

Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive ...

Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti ...

Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, and Nitric Oxide ...

Discovery of the nitric oxide signaling pathway and targets for drug ...

novel drug development exploiting the NO-sGC pathway ... GSNOR has become an important target for developing agents that modulate nitric oxide ...

(PDF) Novel Agents for Cancer Prevention Based on Nitric

Novel Agents for Cancer Prevention Based on Nitric Oxide by B. Rigas published in Biochemical Society Transactions.

Nitric Oxide (NO)-Releasing Macromolecules - Frontiers

the biological functions of NO and to develop novel NO donors. ... The development of organic nitrate- and nitrobenzene-based NO donors ...