[PDF] Looking beyond drivers and passengers in cancer genome ...

Looking beyond drivers and passengers in cancer genome ...

Analyses of cancer genome sequencing data can not only catalog driver and passenger mutations, but can also help identify signatures of DNA ...

Emerging findings show that mutational patterns in cancer genomes can help detect signatures of known and novel DNA damage and repair processes, ...

Reviews Looking beyond drivers and passengers in cancer genome ...

Massive genome sequencing of thousands of tumors from all major cancer types has enabled cataloging of the so-called driver and passenger mutations, and ...

Looking beyond drivers and passengers in cancer genome ...

Massive genome sequencing of thousands of tumors from all major cancer types has enabled cataloging of the so-called driver and passenger mutations.

Looking beyond drivers and passengers in cancer genome ...

Massive genome sequencing of thousands of tumors from all major cancer types has enabled cataloging of the so-called driver and passenger mutations, and ...

Looking beyond drivers and passengers in cancer genome ...

Download Citation | Looking beyond drivers and passengers in cancer genome sequencing data | Cancer arises as a result of acquired changes in the DNA ...

[PDF] Mutational heterogeneity in cancer and the search for new ...

Looking beyond drivers and passengers in cancer genome sequencing data. S ... tumor biology. Expand. 2,667 Citations · PDF. Add to Library. Alert ...

Passenger Mutations in More Than 2500 Cancer Genomes

tumorigenesis beyond standard drivers d. Additive-effects model from germline studies can be repurposed for cancer genomics. Authors. Sushant ...

(PDF) Distinguishing between driver and passenger mutations in ...

PDF | Background In somatic cancer genomes, delineating genuine driver mutations against a background of multiple passenger events is a ...

Providing an optimized model to detect driver genes from ... - Nature

Download PDF. Article; Open access; Published: 28 April 2021 ... Looking beyond drivers and passengers in cancer genome sequencing data.

The Damaging Effect of Passenger Mutations on Cancer Progression

... passenger's harm extends beyond coding regions of the genome. We further ... drivers and passenger load on cancer genomes (Supplementary Information; ref.

Passenger mutations in cancer evolution - OAText

... passengers and drivers in tumor cells may explain some paradoxical cancer ... Looking beyond drivers and passengers in cancer genome sequencing ...

Cancer Genome Landscapes - PMC

A typical tumor contains two to eight of these “driver gene” mutations; the remaining mutations are passengers that confer no selective growth advantage. Driver ...

Prediction of cancer driver genes and mutations - Oxford Academic

... cancer patient cohort and categorizes these into drivers and passengers ... , et al. Global mapping of cancers: the cancer genome atlas and beyond.

DNA Mutations May Not Be the Cause of Cancer

The objective behind sequencing cancer genomes is to look for driver mutations, which increase the mutation rate in the cell, leading to a more ...

Looking beyond drivers and passengers in cancer genome ...

Looking beyond drivers and passengers in cancer genome sequencing data. https ... Navin, The first five years of single-cell cancer genomics and beyond, Genome ...

CScape-somatic: distinguishing driver and passenger point ...

... drivers and passengers, particularly for non-coding regions of the cancer genome. ... Hence, we are interested in seeing whether a ...

Identifying Combinations of Cancer Drivers in Individual Patients

Looking beyond drivers and passengers in cancer genome sequencing data. ... driver genes in personal cancer genomes. [15] Christos M ...

Distinguishing between cancer driver and passenger gene ...

We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, ...

Beyond the exome: the role of non-coding somatic mutations in cancer

This task is complicated by the fact that most mutations within the genome of a cancer cell are 'passenger' mutations which are not directly implicated in ...