[PDF] Mutational signature distribution varies with DNA replication ...

Mutational signature distribution varies with DNA replication timing ...

We show that replication affects the distribution of nearly all mutational signatures across the genome, including those that represent chemical mutagens.

Mutational signature distribution varies with DNA replication timing ...

PDF | Background: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes.

[PDF] Mutational signature distribution varies with DNA replication ...

The results suggest that oxidative damage to the nucleotide pool substantially contributes to the mutational landscape of esophageal adenocarcinoma and ...

Mutational signature distribution varies with DNA replication timing ...

DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes.

Mutational signature distribution varies with DNA replication timing ...

DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes.

Mutational signature distribution varies with DNA replication timing ...

Background: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic ...

Additional file 6: of Mutational signature distribution varies with DNA ...

1. DOI - Is supplement to Mutational signature distribution varies with DNA replication timing and strand asymmetryView PDF. Usage metrics. 187 views. 36 ...

Mutational signature distribution varies with DNA replication timing ...

DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation ...

Widespread impact of DNA replication on mutational mechanisms in ...

We show that replication affects the distribution of nearly all mutational signatures across the genome, including those ... replicating regions (log2 fold-change ...

Topography of mutational signatures in human cancer - PMC

3, May 27th, 2022. Supplementary Material. 1. NIHMS1928262-supplement-1.pdf (8.7MB, pdf) ... Mutational signature distribution varies with DNA replication timing ...

Replication timing alterations are associated with mutation ... - Nature

Download PDF. Article; Open access; Published ... Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Additional file 5: of Mutational signature distribution varies with DNA ...

1. DOI - Is supplement to Mutational signature distribution varies with DNA replication timing and strand asymmetryView PDF. Usage metrics. 1014 views. 108 ...

Mutational signatures association with replication timing in normal ...

Download PDF. Article; Open access; Published ... Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Mechanisms underlying mutational signatures in human cancers

... replication components that constitute the determinant mutational process ... DNA in various ways and can produce particular mutational signatures. For ...

Cell-type specificity of the human mutation landscape with respect to ...

... mutations in 20 autosomal. DNA replication ... Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Mutational Signatures: From Methods to Mechanisms

Mutational signature distribution varies with DNA replication timing and strand asymmetry. Genome Biol. 19:129. 55. Koren A, Polak P, Nemesh ...

Decomposing the mutational landscape of cancer genomes with ...

View PDF; Download full issue. Search ... Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Mutational Signatures of Replication Timing and Epigenetic ...

Our results suggest that great ape mutation spectrum evolution is not driven by epigenetic changes that modify mutation rates in specific genomic regions.

Cancer mutational processes vary in their association with ... - bioRxiv

Mutational signature distribution varies with DNA replication timing and strand asymmetry. Genome Biol 19, 129 (2018). 9. Hand, R ...

Sequence dependencies and mutation rates of localized mutational ...

Download PDF. Research; Open access; Published ... Mutational signature distribution varies with DNA replication timing and strand asymmetry.