[PDF] Roles of XBP1s in Transcriptional Regulation of Target Genes ...

Roles of XBP1s in Transcriptional Regulation of Target Genes - PMC

XBP1s directly regulates the transcription of CCAAT/enhancer-binding protein α (Cebpa), which encodes a key adipogenic transcription factor C/EBPα, by binding ...

(PDF) Roles of XBP1s in Transcriptional Regulation of Target Genes

XBP1s is a potent transcription factor activated during the UPR to increase ER protein folding capacity and restore homeostasis [32] . The ...

Roles of XBP1s in Transcriptional Regulation of Target Genes

XBP1s is involved in several unique mechanisms to regulate the transcription of different target genes by interacting with other proteins to modulate their ...

[PDF] Roles of XBP1s in Transcriptional Regulation of Target Genes

The roles of XBP1s in target genes transcriptional regulation, an active transcription factor that plays a vital role in the unfolded protein response (UPR) ...

Roles of XBP1s in Transcriptional Regulation of Target Genes.

XBP1s is involved in several unique mechanisms to regulate the transcription of different target genes by interacting with other proteins to modulate their ...

Roles of XBP1s in Transcriptional Regulation of Target Genes

Roles of XBP1s in Transcriptional Regulation of Target Genes. Sung-Min Park, Tae-Il Kang, Jae-Seon So. 2021, Biomedicines. PDF · S2 logo ...

Roles of XBP1s in Transcriptional Regulation of Target Genes

Moreover, studies have shown that XBP1s regulates the transcription of diverse genes that are involved in lipid and glucose metabolism and immune responses.

The Biological Roles of XBP1 Isoforms in Pathophysiology - MDPI

Due to the presence of the transcriptional activator domain in its C terminus, XBP1-s can function as a transcriptional regulator targeting a series of genes [ ...

iScience

... Xbp1s impinge on the same target genes in the fat ... transcriptional cross-regulation but cooperation on shared targets across the genome.

XBP1 activates the transcription of its target genes via an ACGT core ...

XBP1s is known to act as a basic region leucine zipper (bZIP) transcription factor activating gene expression by binding to gene regulatory ...

Endoplasmic reticulum unfolded protein response transcriptional ...

The spliced form of XBP1 (XBP1s) functions as a potent transcription factor via frame switch splicing, joining the basic leucine zipper (bZIP) ...

Article XBP1 Controls Diverse Cell Type- and Condition-Specific ...

The transcription factor (TF) XBP1 is a critical effector of the mammalian UPR whose activity is regulated by IRE1, an ER-resident kinase/ ...

[PDF] Regulation of unfolded protein response modulator XBP1s by ...

134 Citations · Roles of XBP1s in Transcriptional Regulation of Target Genes · Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic ...

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by ...

The transcription factor, X-box-binding protein-1 (XBP1), controls the development and maintenance of the endoplasmic reticulum (ER) in multiple secretory cell ...

The unfolded protein response transcription factor XBP1s ...

We show that XBP1s expression significantly diminishes the cognitive decline observed in experimental AD using neuronal-specific transgenic mice ...

The orphan nuclear receptor SHP regulates ER stress response by ...

IRE1α–XBP1s target genes such as Erdj4, Hrd1, and BiP, but not Chop, in ... rect transcriptional target of XBP1s. (J) Sequence of mouse Shp promoter ...

The unfolded protein response transcription factor XBP1s ...

Because XBP1s-target genes are functionally diverse, this UPR transcription factor might attenuate the progression of experimental AD by ...

Enforced dimerization between XBP1s and ATF6f enhances the ...

Activating transcription factor 6 alpha (ATF6α) is a type II transmembrane protein, that under ER stress is translocated to the Golgi apparatus ...

Dual and opposing roles of the unfolded protein response ... - PNAS

As a key regulator of the unfolded protein response, the transcription factor XBP1 activates genes in protein secretory pathways and is required for the ...

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic ...

XBP1u mRNA was selected as an XBP1s transactivation readout because our earlier work showed that XBP1 gene is positively autoregulated by XBP1s ...