[PDF] The Role of Cellular Senescence in the Gastrointestinal Mucosa

The Role of Cellular Senescence in the Gastrointestinal Mucosa

Cellular senescence is emerging as a widespread cellular end point in GI oncology and its importance is becoming increasingly recognized as an ...

The Senescence cascade and the cell-cycle checkpoints that dictate the progression and maintenance of senescence are important in all types of ...

The Role of Cellular Senescence in the Gastrointestinal Mucosa

Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs following either a replicative or an oncogenic ...

The Role of Cellular Senescence in the Gastrointestinal Mucosa

Senescent cells can be identified in vitro because they express senescence-associated β-galactosidase, a marker of increased lysosomal activity. Cellular ...

The role of cellular senescence in the gastrointestinal mucosa

Senescent cells can be identified in vitro because they express senescence-associated β-galactosidase, a marker of increased lysosomal activity.

Cellular senescence in gastrointestinal diseases - ResearchGate

Request PDF | Cellular senescence in gastrointestinal diseases: From pathogenesis to therapeutics | Senescence is a durable cell cycle arrest that can be ...

The Role of Cellular Senescence in Health and Disease - Frontiers

explores the link between cell senescence, intestinal epithelial integrity and gut microbiota. Using a mouse model of loss of function of ...

Comprehensive assessment of cellular senescence in intestinal ...

Therefore, evaluating the involvement of genes related to cellular senescence in UC intestinal inflammation and immunity helps elucidate the ...

Cellular Senescence, Inflammation, and Cancer in the ... - MDPI

The incidence of gastrointestinal tract (GI) diseases, including cancers increases with age, partially due to the accumulation of senescent ...

A new face of old cells: An overview about the role of senescence ...

Cellular senescence is a pivotal factor contributing to aging and the pathophysiology of age-related diseases. Despite the presence of inflammation and ...

The connection between aging, cellular senescence and gut ...

The complexity and heterogeneity of senescent cells, alongside the secretion of senescence-associated secretory phenotype, exacerbate the aging ...

Role of cellular senescence in inflammation and regeneration

Cellular senescence is the state in which cells undergo irreversible cell cycle arrest and acquire diverse phenotypes.

(PDF) Cellular Senescence, Inflammation, and Cancer in the ...

Thus, it is important to find potential senescence biomarkers as targets of novel therapies for GI diseases and disorders including cancers.

Cellular senescence in vivo: From cells to tissues to pathologies

Senescent cells accumulate during aging in a variety of tissues. Although scarce, they could influence tissue function non-cell-autonomously ...

Cellular senescence in lymphoid organs and immunosenescence

The goal of this review is to explore the role of cellular senescence in age-associated lymphoid organ dysfunction and immunosenescence.

Cellular senescence: Neither irreversible nor reversible

Cellular senescence is a critical stress response program implicated in embryonic development, wound healing, aging, and immunity.

[PDF] Cellular senescence: putting the paradoxes in perspective.

The Role of Cellular Senescence in the Gastrointestinal Mucosa · J. PenfieldMarlys A. AndersonLori L. LutzkeKenneth K Wang. Biology, Medicine. Gut and liver.

Emerging Interrelationship Between the Gut Microbiome and ...

It is thus evident that intestinal epithelial, as well as stem cells, exhibit age-dependent cellular senescence which can contribute to known ...

Regulation of intestinal senescence during cholestatic liver disease ...

Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, ...

ELMO1 ameliorates intestinal epithelial cellular senescence via ...

As its name implies, the family plays a crucial role in cytoskeleton rearrangements during phagocytosis, cellular migration, and chemotaxis [25] ...