1 Rab 27 a and Rab 27 b control different steps of the exosome ...

Rab27a and Rab27b control different steps of the exosome ... - Nature

Exosomes are membrane vesicles secreted into the extracellular space by numerous cell types. These nanometre-sized vesicles have a similar ...

Rab27a and Rab27b control different steps of the exosome ...

The molecular mechanisms of exosome biogenesis and secretion are, however, poorly understood. Using an RNA interference (RNAi) screen, we identified five Rab ...

1 Rab27a and Rab27b control different steps of the exosome ...

Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs).

1 Rab 27 a and Rab 27 b control different steps of the exosome ...

A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a leading cause of cell death in women, and the use ...

Rab27a and Rab27b control different steps of the exosome ...

The results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo.

Rab27a and Rab27b control different steps of the - ProQuest

Nevertheless, in some cell types, such as T lymphocytes, exosomes bud at the plasma membrane from endosome-like domains16. Therefore, identification of ...

Rab27a and Rab27b control different steps of the exosome ...

Exosome biogenesis is poorly understood. The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion at different ...

Rab27a and Rab27b control different steps of the exosome ...

The fact that both early and late endosomal Rab proteins have a role in exosome secretion suggests that, according to the cell type, different subpopulations of ...

RAB27B controls palmitoylation-dependent NRAS trafficking and ...

Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12(1):19–30. doi: 10.1038/ncb2000. [DOI] ...

Rab27b, a Regulator of Exosome Secretion, Is Associated With ...

Rab27a and Rab27b regulate exocytosis of multivesicular endosomes and control different steps of the exosome secretion pathway (46-48). Rab27a likely has a ...

Rab27a Supports Exosome-Dependent and -Independent ...

We have recently shown that the small GTPases RAB27A and RAB27B are critically required for exosome secretion by HeLa cells (13). RAB27A/B are known to control ...

KIBRA controls exosome secretion via inhibiting the proteasomal ...

Rab27a and Rab27b share a common function in MVB docking to the PM but the two Rab27 isoforms have different roles in the exosomal pathway.

Rab27b, a Regulator of Exosome Secretion, Is Associated With ...

(B) Immunoblotting of Rab27a and Rab27b in 58As9 cells transfected with Rab27a or Rab27b ... Rab27b control different steps of the exosome secretion pathway. Nat ...

Rab27-Dependent Exosome Production Inhibits Chronic ...

Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12. : 19. –. 30, 1–13 . Google Scholar · Crossref.

Rab7a and Rab27b control secretion of endothelial microRNA ...

With respect to vesicular secretion, Rab11, Rab27a/27b, and Rab35 were found to be essential for exosomal release in different cell lines [12], ...

Functional implications of Rab27 GTPases in Cancer

Recent studies have revealed that Rab27A and Rab27B control exosome secretion in various cell types, including dendritic cells [22], cervical ...

Rab27a and Rab27b control different steps of the exosome ...

Page 1. 1. Rab27a and Rab27b control different steps of the exosome secretion pathway. Matias Ostrowski. 1,2. , Nuno B. Carmo. 3*. , Sophie Krumeich. 1,2*.

Vesicular Trafficking, a Mechanism Controlled by Cascade ... - MDPI

The cascade of inactivation of one Rab/activation of another Rab directs ... Rab27a and Rab27b control different steps of the exosome secretion pathway.

RAB27A - an overview | ScienceDirect Topics

The central role of RAB27 in exosomal secretion has been widely confirmed30–32 and hence this RAB protein is currently the subject of intense investigation.

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

One representative example of Rab27 regulating two distinct steps ... Rab27a and Rab27b control different steps of the exosome secretion pathway.