5|Hydroxymethylcytosine profilings in circulating cell|free DNA as ...

5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as ...

Background: 5-Hydroxymethylcytosine (5hmC) is an important DNA epigenetic modification that plays a vital role in tumorigenesis, progression and prognosis.

5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA ...

5-hmC profiles in children with neuroblastoma correlate with metastatic burden and warrants development as a biomarker of treatment response and outcome.

5-Hydroxymethylcytosine profilings in circulating cell-free DNA as ...

Conclusion: Our study suggested that 5hmC markers derived from plasma cfDNA can served as effective epigenetic biomarkers for minimally invasive ...

5-Hydroxymethylcytosine in circulating cell-free DNA as a potential ...

Methods We used 5hmC-Seal to generate genome-wide 5hmC profiles of plasma cfDNA and bioinformatics analysis to screen differentially hydroxymethylated regions ( ...

5-hydroxymethylcytosine profiles in circulating cell-free DNA ...

5-hydroxymethylcytosine (5-hmC) is an epigenetic marker of open chromatin and active gene expression. We profiled 5-hmC with Nano-hmC-Seal technology using ...

5-Hydroxymethylcytosines in circulating cell-free DNA as a ...

5hmC modifications in cfDNA are promising noninvasive biomarkers for NPC, offering high sensitivity and specificity, particularly for early-stage and EBV- ...

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as ...

... genome-wide profiling of 5hmC in circulating cell-free DNA (cfDNA) and in genomic DNA (gDNA) of paired tumor and adjacent tissues collected ...

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as ...

... genome sequencing technology based on selective chemical capture (hmC-Seal) to firstly generate the 5hmC profiles in the circulating cell-free ...

5-hydroxymethylcytosine profiles in circulating cell-free DNA as ...

AbstractBackground. DNA 5-hydroxymethylcytosine (5hmC) modification is an epigenetic marker involved in a range of biological processes.

5-Hydroxymethylome in Circulating Cell-free DNA as A Potential ...

5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable ...

Genome-wide mapping of 5-hydroxymethylcytosines in circulating ...

The 5hmC-Seal technique has been demonstrated to be a sensitive and robust epigenomic tool for cancer biomarker discovery using circulating cell-free DNA (cfDNA) ...

5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as ...

5-hydroxymethylcytosine Epigenetic Markers in COVID-19-Associated Acute Coronary Syndrome: Insights... ... Background: Studies have reported that 5hmC features in ...

5-Hydroxymethylcytosine signatures in cell-free DNA provide ...

5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis.

5‐Hydroxymethylcytosine signature in circulating cell‐free DNA as a ...

The gDNA and cfDNA 5hmC signatures identified in gene bodies and promoter regions in CRC and AD groups were compared with those in HC group. All ...

Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding ...

5-Hydroxymethylcytosine (5hmC) is a significant DNA epigenetic modification. However, the 5hmC modification alterations in genomic regions ...

Cell-Free DNA Hydroxymethylation in Cancer: Current and ... - MDPI

5-hydroxymethylcytosine (5hmC) is an emerging epigenetic modification formed through the oxidation of 5-methylcytosine (5mC) by ten-eleven translocase (TET) ...

5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as ...

Abstract Background 5-Hydroxymethylcytosine (5hmC) is an important DNA epigenetic modification that plays a vital role in tumorigenesis, progression and ...

Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung ... - MDPI

We performed genome-wide profiling of 5hmC in 97 plasma cfDNA samples obtained from lung cancer patients. Using a machine learning approach, we randomly split ...

Genome-wide profiling of 5-hydroxymethylcytosines in circulating ...

Using the 5hmC-Seal and next-generation sequencing, we profiled genome-wide 5hmC in circulating cell-free DNA (cfDNA) from 342 newly diagnosed patients with MM ...

Prognostic implications of 5-hydroxymethylcytosines from circulating ...

An elevated level of circulating cell-free DNA (cfDNA) has been associated with tumor bulk and poor prognosis in diffuse large B-cell lymphoma ( ...