5O Deciphering resistance mechanisms in cancer

Deciphering resistance mechanisms in cancer: final report of ... - NCBI

The prospective MATCH-R trial (NCT02517892), led by Gustave Roussy, aimed to characterize resistance mechanisms to cancer treatments through ...

Deciphering the Molecular Mechanisms behind Drug Resistance in ...

One of the challenges in oncological treatment is the development of multidrug resistance (MDR), which occurs when tumor cells become resistant to structurally ...

Deciphering drug resistance in gastric cancer - ScienceDirect.com

This article primarily explores the potential mechanisms of chemotherapy resistance in GC patients from five perspectives: cell death, tumor microenvironment, ...

Cancer drug resistance causes and categories identified - EMBL-EBI

“Additionally, we believe that our new systematic approach will be important for understanding genetic mechanisms of resistance to new drugs in ...

Understanding and targeting resistance mechanisms in cancer

The plasma membranes from drug-resistant cancer cells have a different lipid composition compared to those from the parental drug-sensitive ...

Mapping Cancer Drug Resistance Mutations and Mechanisms

If a cancer has become resistant to initial treatment, options for second-line therapies can be limited. Understanding what molecular changes ...

Hallmarks of cancer resistance: iScience - Cell Press

Cancer resistance represents a multifaceted spectrum of mechanisms that enable malignant cells to withstand even the most potent therapeutic ...

Multidrug Resistance in Cancer: Understanding Molecular ...

The mechanism of MDR may also be mediated by the release of drugs outside of the cells. MDR may develop due to oncogene mutations, changes in the tumor ...

Unveiling the mechanisms and challenges of cancer drug resistance

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and ...

Understanding and targeting resistance mechanisms in NSCLC

Resistance mechanisms can be classified as 'on-target' or 'off-target'. On-target resistance occurs when the primary target of the drug is ...

Understanding and targeting resistance mechanisms in cancer - Lei

Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment ...

Deciphering the response and resistance to immune-checkpoint ...

... decipher the mechanisms underlying the response or resistance to ... understanding of resistance to ICIs in advanced lung cancer patients.

Deciphering mechanisms of response and resistance in large-scale ...

In this review, we describe how mouse cancer studies that combine genetic and pharmacologic in vivo screens support precision oncology.

Understanding the Genetic Mechanisms of Cancer Drug Resistance ...

before receiving treatment, while 'acquired resistance' refers to resistance mechanisms that develop after the drug treatment of tumors that are initially ...

Mechanisms and insights into drug resistance in cancer - Frontiers

In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism.

5O Deciphering resistance mechanisms in cancer - ResearchGate

5O Deciphering resistance mechanisms in cancer: Insights from the final report of MATCH-R study with focus on molecular drivers.

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Advances in drug resistance mechanism research are required to define both common and unique targetable nodes across cancer entities, based on which rational ...

Molecular chess? Hallmarks of anti-cancer drug resistance

Cancers can employ several resistance mechanisms, either sequentially or concurrently to evade drug treatment. Four examples are described to ...

Clone Wars: Quantitatively Understanding Cancer Drug Resistance

Drug resistance can also occur through adaptive, potentially reversible mechanisms such as immunosuppressive signaling, for example via T- ...

Understanding and overcoming mechanisms of tumor resistance

Foreword · Towards an integrated understanding of immunotherapy resistance · Commentary · Antigen-presenting dendritic cells as targets for cancer ...