A 2A receptor

Adenosine A2A receptor ... The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.

Adenosine A2A Receptor - an overview | ScienceDirect Topics

Adenosine A2A Receptor ... Adenosine A2A Receptor is a subtype of adenosine receptors that is Gs-protein-coupled and can increase intracellular cAMP levels, ...

Human Adenosine A2A Receptor: Molecular Mechanism ... - Frontiers

In this review we analyze the structural data reported for A 2A R that described for the first time the binding of mode of antagonists.

Adenosine A2A Receptors in Psychopharmacology: Modulators of ...

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting a wide range of neuropsychiatric functions by interacting with and ...

The A2A-adenosine receptor: a GPCR with unique features? - PMC

The A2A-adenosine receptor is a prototypical Gs-coupled receptor. However, the A2A-receptor has several structural and functional characteristics that make ...

Adenosine A2A Receptor as a Drug Discovery Target

Following the discovery of adenosine, almost a century of intense research on adenosine receptors has led to the selection of the adenosine A2A receptor as a ...

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

This review will discuss the role of the adenosine-A2AR pathway in the tumor microenvironment and summarize recent advances of A2AR-cancer related studies.

Adenosine A2A Receptor - an overview | ScienceDirect Topics

Adenosine A2A Receptor ... The adenosine A2A receptor (A2AR) is a G-protein-coupled receptor that binds to adenosine, an important intermediate in the pathway of ...

A 2A receptor - IUPHAR/BPS Guide to PHARMACOLOGY

The IUPHAR/BPS Guide to Pharmacology. A 2A receptor - Adenosine receptors. Detailed annotation on the structure, function, physiology, pharmacology and ...

The caffeine-binding adenosine A2A receptor induces age-like HPA ...

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), ...

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite ...

Single-molecule visualization of human A 2A adenosine receptor ...

Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as constitutively activating mutations (CAMs), ...

Adenosine receptor - Wikipedia

There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a different gene. The adenosine receptors are commonly ...

Crystal structure of the adenosine A2A receptor bound to an ... - PNAS

Here we report the crystal structure of A 2A receptor bound to compound 1 (Cmpd-1), a novel A 2A R/N-methyl d-aspartate receptor subtype 2B (NR2B) dual ...

Adenosine A2A Receptors - Tocris Bioscience

Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high ...

Anti-Human Adenosine A2A Receptor (ext.) Antibody - Alomone Labs

Anti-Human Adenosine A2A Receptor (ext.) Antibody (#AAR-007) from Alomone Labs is a highly specific rabbit polyclonal Ab directed against the human protein.

Retrograde adenosine/A2A receptor signaling facilitates excitatory ...

We identified adenosine/A 2A receptor (A 2A R) as a retrograde signaling pathway underlying presynaptic long-term potentiation (LTP) at a hippocampal ...

Adenosine A2A receptor antagonist treatment of Parkinson's disease

A 2A receptor blockade might thus alleviate motor abnormalities in parkinsonian patients by limiting the hyperphosphorylation of striatal glutamatergic ...

Identification of Novel Adenosine A2A Receptor Antagonists by ...

The polar piperazine substituent is proposed to reach into the region of the binding site occupied by ribose in the natural agonist ligand ...

A 2A receptor (aa2ar_human) - GPCRdb

FAMILY · Class A (Rhodopsin) Nucleotide receptors Adenosine receptors A2A receptor · GENE · ADORA2A (ADORA2) · ORGANISM · Human (Homo sapiens) · ALT. NAMES · Adenosine ...