A Comprehensive Analysis of Alterations in DNA Damage Repair ...

Esophageal squamous cell cancer (ESCC) is a common malignancy with a poor 5-year overall survival in China. Altered DNA damage repair (DDR) ...

These findings suggest that DSB repair pathways were significantly altered in ESCC and inhibiting DSB repair pathways might enhance the radio-sensitivity of ...

Comprehensive analysis of DNA damage repair in squamous cell ...

Key findings: This study was conducted on a total of 1374 SCC patients and 402 DNA damage repair genes. Two subtypes were established using ...

A Comprehensive Analysis of Alterations in DNA Damage Repair ...

Altered DNA damage repair (DDR) pathways are associated with a predisposition to cancer and contribute to therapeutic response and resistance in ...

Comprehensive analysis of DNA damage repair deficiency in ...

Background: Disruption of the DNA damage repair (DDR) gene is related to cancer progression, treatment selection, and is subjected to radiation ...

Comprehensive analysis of DNA damage repair genes reveals ...

In an effort to improve treatment strategies and outcomes, DNA damage repair (DDR) pathways have been introduced as a new target in PC and in ...

Alterations in DNA damage response and repair genes as potential ...

In this multicohort study, we investigated the prognostic role of DDR gene mutations in GI cancer patients receiving ICIs. Moreover, our study ...

Alterations of DNA damage response pathway: Biomarker and ...

Therefore, DNA repair is crucial for maintaining genome stability. Multiple mechanisms involve DNA damage response (DDR) system: direct repair (DR), base ...

129P Comprehensive analysis of DNA damage repair deficiency ...

DNA damage repair (DDR) system play key roles in maintaining human genomic stability, disruption of which is observed in many cancers and related to cancer ...

Alterations of DNA damage repair in cancer: from mechanisms to ...

Abstract: DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of genetic material. However, different endogenous and exogenous ...

A Comprehensive Analysis of Alterations in DNA Damage Repair ...

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell ...

DNA Damage Response and Repair Gene Alterations Are ...

However, complex mechanisms are in place to detect DNA damage and initiate various repair pathways. ... In this study, we sought to determine whether alterations ...

Analysis of mutations in DNA damage repair pathway gene ... - Nature

DNA damage repair (DDR) pathway is required in response to DNA damage Gene mutations in DDR pathway play an important role in different stages ...

Landscape of DNA damage response gene alterations in breast ...

DNA damage response (DDR) gene alterations are prevalent in breast cancer (BC) and important for treatment decisions. Intensive studies on DDR alterations in ...

Pan-sarcoma analysis of DNA damage response pathway ...

Background: Alterations in DNA damage response (DDR) pathways contribute to genomic instability and malignant progression and have been shown to be of ...

DNA Damage Repair Profiles Alteration Characterize a ... - Frontiers

We investigated DNA damage repair (DDR) alterations in HCC by integrating multi-omics data. HCC patients were classified into two heterogeneous subtypes with ...

Pan-sarcoma analysis of DNA damage response pathway ...

Comprehensive analysis of individual histologic subtypes is in progress. • Alterations in DNA damage response (DDR) pathways contribute to genomic ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through interacting with other important players of DNA ...

Alterations in DNA Damage Repair Genes in Primary Liver Cancer

Comparative analysis indicates that patients with DDR mutations have significantly higher tumor mutation burden. Among the patients with DDR mutations, 26.1 ...

Genomic and Molecular Landscape of DNA Damage Repair ...

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations ...