A DNA|Dependent Protease Involved in DNA|Protein Crosslink Repair

A DNA-dependent protease involved in DNA-protein crosslink repair

We identify the metalloprotease Wss1 as being crucial for cell survival upon exposure to formaldehyde and topoisomerase 1-dependent DNA damage.

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

We identify the metalloprotease Wss1 as being crucial for cell survival upon exposure to formaldehyde and topoisomerase 1-dependent DNA damage.

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

Genome integrity and hence cell viability are constantly threat- ened by DNA damage, originating from exogenous and endoge- nous sources ( ...

A DNA-dependent protease involved in DNA-protein crosslink repair.

A DNA-dependent protease involved in DNA-protein crosslink repair. · Author information · Abstract · Full text links · References · Citations & impact · Data · Similar ...

DNA–protein crosslink proteases in genome stability - Nature

Thus, the fidelity of DNA replication across DPCs and the accuracy of DPC repair pathways are pivotal in avoiding genomic instability, which can ...

DNA–protein cross-link repair: what do we know now?

When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction ...

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

Semantic Scholar extracted view of "A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair" by Julian Stingele et al.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

Our results suggest that the DNA-dependent activity of the SPRTN/Wss1 protease family is critical for its function in vivo. This activity is ...

Editorial: The repair of DNA–protein crosslinks - Frontiers

SPRTN is a replication-coupled protease that digests both break-associated DPC substrates (e.g., topoisomerase DPCs or TOP-DPCs) and DPC ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of ...

Function and evolution of the DNA-protein crosslink proteases Wss1 ...

The proteases Wss1 and SPRTN degrade DPCs and have emerged as crucially important DNA repair enzymes. Their protective role has been described in various model ...

PARP1-dependent DNA-protein crosslink repair - Nature

DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), ...

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

Request PDF | A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair | Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV ...

Ubiquitin signaling and the proteasome drive human DNA–protein ...

DNA–protein crosslinks (DPCs) are large cytotoxic DNA lesions that form following exposure to chemotherapeutic drugs and environmental chemicals ...

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

Related reading · A model for the mechanism of human topoisomerase I · STAP retracted. · Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs ...

A DNA-dependent protease involved in DNA-protein crosslink repair.

Toxic DNA-protein Crosslinks (DPCs) Arise By Ionizing Irradiation And UV Light, Are Particularly Caused By Endogenously Produced Reactive Compounds Such As ...

The protease SPRTN and SUMOylation coordinate DNA-protein ...

show that ubiquitylation and SUMOylation of DNA-protein crosslinks is linked to repair by SPRTN during DNA replication. Blocking. SUMOylation ...

Protease WSS1A, the Endonuclease MUS81, and the ...

The pathways of DNA-protein crosslink repair in plants are characterized by the protease WSS1A, the DNA endonuclease MUS81, and tyrosyl-DNA phosphodiestera.

Mechanisms of DNA–protein crosslink repair - Semantic Scholar

Enzymatic Processing of DNA–Protein Crosslinks · Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease · Targeting ...

DNA-dependent protease activity of - H1 Connect

DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA. Mórocz M et al. Nucleic Acids Research. 2017 ...