A Newly Uncovered Mechanism Underlying Resistance to Immune ...

The results of this study suggest that resistance to immune checkpoint inhibitors may arise, in part, due to hypoxia-mediated expression of BIRC2.

Uncovering the mechanisms underlying lack of response to ...

Immune cells targeting a tumour Uncovering the mechanisms underlying ... uncover new insights and improve our understanding of disease.

Mechanisms of tumor resistance to immune checkpoint blockade ...

Based on the analysis of a panel of syngeneic melanoma mouse models, a melanocytic plasticity signature was uncovered to predict the response to ICB and the ...

Researchers find metabolic mechanism that blocks immune ...

New research has discovered why some cancers don't respond to immunotherapy treatment: A metabolite transporter within the tumor ...

Acquired Resistance to Immune Checkpoint Blockades - NCBI

To clarify the underlying resistance mechanisms to immunotherapy, Sharma et al. introduced a three-category classification of primary resistance ...

Mechanisms underlying response and resistance to immune ...

A study of lung cancer with 14 ICB-resistant tumor samples also revealed the homozygous loss of B2M in a patient who acquired resistance to combined anti-PD-L1 ...

Mechanisms of resistance to immune checkpoint inhibitors - Nature

However, initial response appears to be a binary event, with most non-responders to single-agent ICI therapy progressing at a rate consistent ...

Mechanisms of Resistance to Immune Checkpoint Blockade

The emergence of immune checkpoint blockade therapies over the last decade has transformed cancer treatment in a wide range of tumor types.

Mechanisms of immune checkpoint inhibitors - Nature

... immunity in Fig. 5. These newly discovered immune checkpoints provide ideas to address primary and acquired resistance to PD-1/PD-L1 therapy ...

Hallmarks of response, resistance, and toxicity to immune ...

A major mechanism underlying tumor immune evasion involves engagement of the immune checkpoint pathways. ... mechanisms underlying resistance ...

Predictive biomarkers and mechanisms underlying resistance to ...

Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a variety of tumors, but resistance during treatment ...

Resistance Mechanisms to Anti-PD Cancer Immunotherapy

A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging. Cell 174:1373–87.e19.

Immune Resistance Mechanisms and the Road to Personalized ...

A systematic approach to understanding the underlying cellular and molecular contributors to resistance in ICB treatment. •. Analysis of novel ...

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

This review provides an overview of immune checkpoint blockade therapy from a basic biology and immunologic perspective for the cancer research community.

Phenotypic switching as a non-genetic mechanism of resistance ...

In ADCC, antibodies bind to specific cell surface antigens expressed on cancer cells, such as the epidermal growth factor receptor (EGFR), and recruit immune ...

Many ways to resistance: How melanoma cells evade targeted ...

The identification of mechanisms underlying the switch from a drug sensitive to a drug resistant phenotype has been the focus of melanoma research in the past ...

A research team searches for every gene that helps tumors evade ...

... immune response. Overall, the work revealed both cancer-specific resistance pathways and mechanisms of immune evasion that are shared by ...

PARP inhibitor resistance: the underlying mechanisms and clinical ...

Recently, a case report results indicated that PARPi combined with CDK4/6 inhibitor (palbociclib) revealed more excellent therapeutic effects ...

Tag: immune checkpoint inhibitors

A Newly Uncovered Mechanism Underlying Resistance to Immune Checkpoint Inhibition ... Immune checkpoint inhibition is a form of cancer immunotherapy that works by ...

Featured Research from the Seattle Children's Research Institute

May 16, 2023 – Researchers in the Center for Immunity and Immunotherapies have discovered a new mechanism in human mast cells: They express an inhibitory ...