A Novel Approach for Modeling Biphasic Dose

A Novel Approach for Modeling Biphasic Dose–Response Curves

We consider three cases. First, the four-parameter logistic (4-PL) curve is considered a standard for the modeling of symmetric dose–response profiles.

A Novel Approach for Modeling Biphasic Dose–Response Curves

A Novel Approach for Modeling Biphasic Dose–Response Curves.

A General Approach to Modeling Biphasic Relationships

Biphasic relationships can be found throughout the sciences, especially in the dose-response relationships of pharmacology, toxicology, agriculture, ...

0000-0003-1929-6617 - ORCID

A Novel Approach for Modeling Biphasic Dose–Response Curves. Statistics in Biopharmaceutical Research. 2023-10-02 | Journal article.

A General Approach to Modeling Biphasic Relationships

... Inverted U-shaped and U-shaped dose-response curves can be described by many nonmonotonic hormetic dose-response models such as the Brain-Cousens model, 34 ...

Modelling biphasic hormetic dose responses to predict sub-NOAEL ...

Hormesis modelling represents a trend analysis based on multiple measurements and takes into account an estimated maximum increase to be achieved for the ...

biphasic dose-response curve: Topics by Science.gov

Instead, we have applied a mathematical modeling approach to interpret the full dose-response curve in a new way. The developed model predicts a non-steady ...

An automated fitting procedure and software for dose-response ...

141 Citations · A Novel Approach for Modeling Biphasic Dose–Response Curves · Inclusion of Control Data in Fits to Concentration–Response Curves Improves ...

A unified approach to dissecting biphasic responses in cell signaling

In-built competing effects are present at different levels in signaling networks, starting from basic biochemical building blocks to the ...

Behavioral Posology: A Novel Paradigm for Modeling the Healthy ...

A behavioral frequency response analysis (BFRA) of the model demonstrates how behavior repetition may result in a hormetic dose–response ...

Dose-Response Analysis Using R | PLOS ONE

These models are parameterized using a unified structure with a coefficient b denoting the steepness of the dose-response curve, c, d the lower and upper ...

Modeling Biphasic, Non-Sigmoidal Dose-Response Relationships

Here, we examine curve fitting methods for hormetic dose-response relationships where low and high doses of an effector produce opposite responses.

Hormesis Defined - PMC

Examples include many chemicals, temperature, radiation, exercise, energy intake and others. A biphasic dose response curve from work done in my laboratory more ...

[PDF] Statistical models for biphasic dose-response relationships ...

This review explored the applications of statistical models used to characterize hormesis dose-response relationships in toxicological ...

A Universal Delayed Difference Model Fitting Dose-response Curves

We propose a novel dynamic model (DRDM) for fitting to various types of dose-response curves, which can reflect the dynamic trend of the population growth ...

Statistical models for biphasic dose-response relationships ...

Keywords: Hormesis, dose-response curves, toxicology, mathematical models, effective doses. INTRODUCTION. Toxicology is a branch of science concerned with the ...

(PDF) Statistical models for biphasic dose-response relationships ...

These models are used to describe either U-shaped or inverted U-shaped dose-response relationships and to compute hormesis quantities. This review explored the ...

How to fit a Biphasic Dose Response Curve using R? - Stack Overflow

Two questions (please read and answer both): 1)Your plotted fit looks more like a bell-shaped curve than a two-phase dose response. Please ...

Biphasic Dose-Response Induced by Phytochemicals: Experimental ...

The term hormesis described the phenomenon in which a chemical is able to induce biologically opposite effects at different doses; as dose ...

A General Approach to Modeling Biphasic Relationships

The approach suggested here can be elaborated to accommodate these possibilities (see Supporting Information). Because the dose-response curve is the integral ...