A Review of Approaches to Potentiate the Activity of Temozolomide ...

We review some of the approaches investigated to counteract these mechanisms of resistance to TMZ, including the use of chemosensitizers and drug delivery ...

This paper is a bit amateurishly written. It is with sadness that I must recommend rejection as the paper now stands. The subject this paper purports to tackle ...

A Review of Approaches to Potentiate the Activity of Temozolomide ...

Thus, there is an urgent need to devise strategies to potentiate TMZ activity, to overcome drug resistance, and to reduce dose-dependent AEs. Here, we analyze ...

A Review of Approaches to Potentiate the Activity of Temozolomide ...

The current standard of care for GBMs include maximally safe tumor resection, followed by concurrent adjuvant radiation treatment and chemotherapy with the DNA ...

Overcoming Resistance to Temozolomide in Glioblastoma - NCBI

A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance. Int. J. Mol. Sci. 2024;25 ...

Strategies increasing the effectiveness of temozolomide at various ...

As a result, there is a need to design a more specific and noninvasive approach to target GBL. Temozolomide (TMZ) is currently first-line chemotherapy for ...

Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose ...

ABT-888 potentiates temozolomide activity in HCT116 cells. A. Potentiation assay was carried out as described in Materials and Methods. The concentration of ABT ...

How to sensitize glioblastomas to temozolomide chemotherapy

Temozolomide (TMZ) is a methylating agent used as the first-line drug in the chemotherapy of glioblastomas. However, cancer cells eventually acquire ...

Temozolomide Nanoparticles for Targeted Glioblastoma Therapy

A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance. International Journal of Molecular Sciences ...

Potentiation of temozolomide activity against glioblastoma cells by ...

Glioblastoma (GBM) is a highly aggressive and lethal cancer of the central nervous system (CNS) [1]. The current standard therapy for GBM patients comprises ...

Roscovitine effectively enhances antitumor activity of temozolomide ...

We observed that TMZ treatment following a pre-treatment with RSV significantly enhanced chemo-sensitivity and suppressed the growth of glioma ...

Potential Strategies Overcoming the Temozolomide Resistance for ...

The current knowledge of different resistance mechanisms, novel strategies for enhancing the effect of TMZ, and emerging therapeutic approaches to eliminate ...

Targeting autophagy to sensitive glioma to temozolomide treatment

TMZ treatment results in G2/M phase arrest, although apoptosis occurs in a few of the treated glioma cells. CQ could potentiate the ...

Polymeric and small molecule-conjugates of temozolomide as ...

Temozolomide (TMZ), an imidazotetrazine, is a second-generation DNA alkylating agent used as a first-line treatment of glioblastoma multiforme (GBM).

An overview of glioblastoma multiforme and temozolomide resistance

Figure 5 Detailed TMZ resistance mechanism in GBM. (A) Enzyme MGMT reverses the methylation O6-MeG by removing a methyl group, leading to increased cellular ...

Adjuvant Temozolomide Chemotherapy With or Without Interferon ...

Moreover, MGMT expression is markedly decreased with the combination of temozolomide and interferon alfa. A previous study of 30 patients with ...

Polymer–Temozolomide Conjugates as Therapeutics for Treating ...

A series of polymer–drug conjugates based on 2-methacryloyloxyethyl phosphorylcholine (MPC) was prepared with the glioblastoma drug temozolomide (TMZ) as ...

Central nervous system penetration and enhancement of ... - Nature

Temozolomide shows activity against medulloblastoma, the most common malignant paediatric brain tumour. Poly(ADP-ribose) polymerase (PARP) ...

Temozolomide and Treatment of Malignant Glioma 1 - AACR Journals

Studies have shown that treatment of human tumor cells with temozolomide induced an increase in the activity of PARP, which is believed to be involved in ...

effects of temozolomide (TMZ) therapy on survival. Mice with...

Using this method, we show that patient-derived glioblastoma (GBM) samples with acquired temozolomide (TMZ) resistance display elevated HR and MMEJ activity, ...