A ferredoxin|dependent dihydropyrimidine dehydrogenase in ...

A ferredoxin-dependent dihydropyrimidine dehydrogenase in ...

Dihydropyrimidine dehydrogenase (PydA) catalyzes the first step of the reductive pyrimidine degradation (Pyd) pathway in bacteria and ...

A ferredoxin-dependent dihydropyrimidine dehydrogenase in ...

Dihydropyrimidine dehydrogenase (PydA) catalyzes the first step of the reductive pyrimidine degradation (Pyd) pathway in bacteria and eukaryotes, ...

A Ferredoxin-dependent Dihydropyrimidine Dehydrogenase in ...

PDF | Dihydropyrimidine dehydrogenase (PydA) catalyzes the first step of the reductive pyrimidine degradation (Pyd) pathway in bacteria and eukaryotes,.

A ferredoxin-dependent dihydropyrimidine dehydrogenase in ...

A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens-article.

Dihydropyrimidine Dehydrogenase - an overview - ScienceDirect.com

This enzyme converts uracil to a distinct molecule termed 5,6-dihydrouracil and thymine to 5,6-dihydrothymine. An enzyme called dihydropyrimidine dehydrogenase ...

Dihydropyrimidine dehydrogenase (DPD) enzyme deficiency - eviQ

DPD deficiency occurs in patients who carry genetic variations in the dihydropyrimidine dehydrogenase (DPYD) gene. Fluoropyrimidine toxicity. About 10-40% of ...

Dihydropyrimidine Dehydrogenase - an overview - ScienceDirect.com

DPYD is a minor phase I metabolizing enzyme, considered the initial and rate-limiting enzyme for the catabolism of pyrimidines such as uracil and thymine. It is ...

Dihydropyrimidine dehydrogenase (NADP+) - Wikipedia

In humans the enzyme is encoded by the DPYD gene. ... It is the initial and rate-limiting step in pyrimidine catabolism. ... It catalyzes the reduction of uracil ...

DPD deficiency | Treatment for cancer

Having a deficiency in the DPD enzyme could make the side effects of certain chemotherapy drugs worse. For some people, these side effects can be life ...

Escherichia coli Dihydropyrimidine Dehydrogenase Is a Novel NAD ...

Mammalian DPD, the first and rate-limiting enzyme of the reductive pyrimidine catabolic pathway, catalyzes the NADPH-dependent reduction of uracil and thymine ...

Uncovering the roles of dihydropyrimidine dehydrogenase in fatty ...

The studies presented herein describe a novel role for DPYD in hepatocyte metabolic regulation as a modulator of hepatic steatosis.

Dihydropyrimidine Dehydrogenase Deficiency - AccessPediatrics

The rate-limiting step in the degradation of uracil and thymine is catalyzed by the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzyme ...

Crystal structure of dihydropyrimidine dehydrogenase, a major ...

Dihydropyrimidine dehydrogenase catalyzes the first step in pyrimidine degradation: the NADPH‐dependent reduction of uracil and thymine to the corresponding ...

Profound variation in dihydropyrimidine dehydrogenase activity in ...

Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), ...

preA - Escherichia coli (strain K12) | UniProtKB | UniProt - UniProt

Recommended name. NAD-dependent dihydropyrimidine dehydrogenase subunit PreA · EC number. EC:1.3.1.1 (UniProtKB | ENZYME | Rhea ) · Short names. DPD · Alternative ...

AF_AFQ8X643F1: Computed structure model of NAD ... - RCSB PDB

COMPUTED STRUCTURE MODEL OF NAD-DEPENDENT DIHYDROPYRIMIDINE DEHYDROGENASE SUBUNIT PREA ... There are no experimental data to verify the accuracy of this computed ...

Knowledge Hub - Dihydropyrimidine dehydrogenase (DPD) deficiency

Severe fluoropyrimidine-related toxicity is associated with four major DPYD variants: c.1905+ 1G>A (rs3918290) DPYD*2A; c.2846A>T (rs67376798); c.1679T>G ...

Escherichia coli K-12 substr. MG1655 dihydropyrimidine ... - BioCyc

PreA was shown to form a complex with PreT; PreAT has NAD+-dependent dihydropyrimidine dehydrogenase activity [Lasserre06, Mihara08, Yoshioka21].

Dihydropyrimidine Dehydrogenase (DPYD), 3 Variants

Dihydropyrimidine dehydrogenase is an enzyme encoded by the DYPD gene and is responsible for the metabolism of 5-fluorouracil (5-FU).

Dihydropyrimidine Dehydrogenase Deficiency - SpringerLink

Dihydropyrimidine dehydrogenase (DPD) deficiency (McKusick 274270) is a, clinically heterogeneous, autosomal recessive disease. DPD (EC 1.3.1.2) catalyzes ...