A hidden source for T cell epitopes in the SARS|CoV|2 genome

A hidden source for T cell epitopes in the SARS-CoV-2 genome

Viral peptides encoded by unconventional translated regions in the SARS-CoV-2 genome are presented on the surface of infected cells and invoke a strong ...

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from ...

First, antigen processing and presentation is a multi-step biological pathway that includes source protein degradation by the proteasome, peptide cleavage by ...

Selective and cross-reactive SARS-CoV-2 T cell epitopes in ...

We therefore assessed the overall distribution of the 142 T cell epitopes mapped among all SARS-CoV-2 proteins compared with the relative size of each SARS-CoV- ...

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by ...

Given the fact that a substantial proportion of them are naïve T cells and that T cell epitopes are well conserved among SARS-CoV-2 variants, ...

The HLA-II immunopeptidome of SARS-CoV-2: Cell Reports

Although the presence of a large number of potential T cell epitopes in the viral genome offers a wide range of candidates, it can also present a challenge in ...

T cell response to intact SARS-CoV-2 includes coronavirus cross ...

SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell ...

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from ...

Some peptides from out-of-frame ORFs elicited T cell responses in a humanized mouse model and individuals with COVID-19 that exceeded responses ...

Bioinformatics prediction of B and T cell epitopes within the spike ...

We therefore, proposed a set of B and T cell epitopes based on Immune Epitope Database, homologous epitopes for nAbs in convalescent plasma post SARS CoV ...

A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell ...

Immunogenicity of CoVac-1 was determined in terms of CD4+ and CD8+ T cell responses to the six SARS-CoV-2 HLA-DR vaccine T cell epitopes as well ...

T-React. Epitopes Track Settings - UCSC Genome Browser

Using these peptide sets, the authors "demonstrate the presence of S-reactive CD4+ 52 T cells in 83% of COVID-19 patients, 53 as well as in 34% of SARS-CoV-2 ...

SARS-CoV-2 infected cells present HLA-I peptides from canonical ...

Identification of viral peptides presented on class I human leukocyte antigen (HLA-I) can reveal epitopes for recognition by cytotoxic T cells ...

BCEDB: a linear B-cell epitopes database for SARS-CoV-2

The virus has gone numerous mutations to replicate faster, which can overwhelm the immune system of the host. Linear B-cell epitopes are ...

Leveraging T-cell receptor – epitope recognition models ... - Frontiers

To characterize CD8+ T-cell response to SARS-CoV-2 epitopes unique to the virus (SC2-unique) or shared with other coronaviruses (CoV-common), we trained a large ...

Structural basis of biased T cell receptor recognition of an ...

Although numerous SARS-CoV-2 CD8+ T cell epitopes have been identified, the molecular basis underpinning T cell receptor (TCR) recognition of ...

Immunoinformatics design of a structural proteins driven ... - Nature

This study aims to provide a peptide-based multi-epitope vaccine effective against various severe acute respiratory syndrome coronavirus 2 strains.

Identification of Targets of CD8 + T Cell Responses to Malaria Liver ...

To identify antigenic epitopes in a stringent murine malaria immunisation model, we performed a systematic profiling of H2b-restricted peptides predicted from ...

Understanding the B and T cell epitopes of spike protein of severe ...

The present study followed computational approaches to identify B- and T-cell epitopes for the spike (S) glycoprotein of SARS-CoV-2 by its interactions with the ...

T cell epitope mapping reveals immunodominance of ... - bioRxiv

A. O. Gang, S. R. Hadrup, SARS-CoV-2 genome-wide T cell epitope mapping reveals ... Doherty, Hidden epitopes emerge in secondary influenza virus- ...

Variations in SARS-CoV-2 Spike Protein Cell Epitopes ... - Frontiers

Our findings provided an important snapshot of temporal and geographical distributions on SARS-CoV-2 S protein cell epitopes and glycosylation sites.

IEDB Predictions Track Settings

Parallel bionformatic predictions identified a priori potential B and T cell epitopes for 2019-nCoV. The independent identification of the same regions using ...