A model of DNA damage response activation at stalled replication ...

Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA ...

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a ...

(PDF) A model of DNA damage response activation at stalled ...

PDF | The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and.

Stalled DNA Replication Fork | Learn Science at Scitable - Nature

This DNA damage shifts the signal cascade to the DNA damage response branch. In yeast, the result is the activation of Chk1 proteins (which have a different ...

a Master Conductor of Cellular Responses to DNA Replication Stress

A model for ATR activation. The DNA damage signaling pathway regulated by the ATR–ATRIP kinase (Box 1 and Table 1) responds to several types of DNA damage and ...

A DNA replication fork-centric view of the budding yeast DNA ...

The DNA damage response (DDR) checkpoint is activated when DNA is damaged or when DNA replication forks stall. The DDR checkpoint plays a critical role in ...

A model of DNA damage response activation at stalled replication ...

By Christopher Bruhn and Marco Foiani; Abstract: The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting ...

ASPM promotes ATR-CHK1 activation and stabilizes stalled ... - PNAS

ASPM depletion results in failed fork restart and nuclease MRE11-mediated nascent DNA degradation at the stalled replication fork. The overall ...

The DNA damage response during DNA replication - ScienceDirect

DNA replication represents a dangerous moment in the life of the cell as endogenous and exogenous events challenge genome integrity by interfering with the ...

A model of DNA damage response activation at stalled replication ...

List of references · Branzei, D. & Foiani, M. · Zou, L. DNA replication checkpoint: new ATR activator identified. · Min, W. et al. · Smits, V. A., Reaper, P. M. & ...

The DNA damage checkpoint response to replication stress - Frontiers

When replication forks stall, a signaling cascade mediated by DNA damage checkpoint kinases is activated, spreading checkpoint signaling to a number of ...

(PDF) A model of DNA damage response activation at stalled ...

DOI: 10.1038/S41467-019-13610-7) The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles.

Replication Stress Drives Constitutive Activation of the DNA ...

Exposure of non-GSC to low-level exogenous RS generated radiation resistance in vitro, confirming RS as a novel determinant of radiation resistance in tumor ...

Hallmarks of DNA replication stress

Depend- ing on the type of stress interfering with replication forks, cells activate multiple response pathways to stabilize, repair, and.

DNA Damage Response - R&D Systems

Upon sensing DNA damage or stalls in replication, cell cycle checkpoints are activated to arrest cell cycle progression to allow time for repair before the ...

A model for ATL-1 activation in response to replication fork stalling...

ATR primarily responds to UV damage and replication stress, yet may also function with ATM in the checkpoint response to DNA double-strand breaks (DSBs), ...

Damage-induced DNA replication stalling relies on MAPK-activated ...

Our results imply a direct impact of the p38–MAP kinase-activated protein kinase 2 (MK2) kinase pathway on the cellular response to ...

A Central Role for DNA Replication Forks in Checkpoint Activation ...

The checkpoint proteins Rad53 and Mec1-Ddc2 regulate many aspects of cell metabolism in response to DNA damage. We have examined the relative importance of ...

HIV Vpr Modulates the Host DNA Damage Response at Two ...

Mutational analyses of Vpr revealed that DNA damage and DDR activation are independent from repression of HR and Vpr-mediated cell cycle arrest. Moreover, we ...

Mechanisms for stalled replication fork stabilization: new targets for ...

When replication forks are stalled, the increased ssDNA–RPA level will activate the ATR/CHK1‐dependent replication checkpoint, which suppresses origin firing in ...