A non|canonical role of somatic Cyclin D/CYD|1 in oogenesis and in ...

A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis and in ...

First, we show that the canonical G1-S cyclin, Cyclin D/CYD-1, regulates reproductive fidelity from the uterine tissue of wild-type worms. Then, we show that ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and ...

Our study reveals the unrecognized cell non-autonomous interaction of CYD-1 and FOXO/DAF-16 in reproductive aging and the regulation of oogenesis.

A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis and in ...

Fig 1. CYD-1 ensures optimal oocyte quality in wild-type. (A) A diagrammatic representation of the right arm of C. elegans gonad ...

A non-canonical role of somatic CYCLIN D/CYD-1 in - ProQuest

Working Paper. A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state. Rautela ...

(PDF) A non-canonical role of somatic CYCLIN D/CYD-1 in ...

We find that activated FOXO/DAF-16 destroys the somatic gonad tissues like the sheath cells, and transcriptionally prevents the spermatogenesis-to-oogenesis ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state ... bioRxiv. Dev ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state · Abstract · List of references.

Arnab Mukhopadhyay on X: "A brand new #preprint led by ⭐grad ...

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state ...

Non-canonical functions of cell cycle cyclins and cyclin-dependent ...

In addition, cyclin D-CDKs were shown to phosphorylate several transcription factors, thereby linking cell cycle and transcription (Table 1). Cyclin D–CDK4 ...

Functions of cyclins and CDKs in mammalian gametogenesis - PMC

The holoenzymes formed by cyclin D and CDK phosphorylate retinoblastoma protein (pRB); this phosphorylation event inhibits the binding of pRB to E2F ...

Involvement of the D-Type Cyclins in Germ Cell Proliferation and ...

Overall, cyclin D2 seems to play a role at the crucial differentiation step of undifferentiated spermatogonia into A1 spermatogonia. Cyclin D3 is expressed in ...

The role of cyclins in the development and progression of prostate ...

These findings suggest that cyclin A1 plays a vital role in prostate cancer invasion and metastatic potential. 5.1.1. VEGF signaling pathway is dependent on ...

Cyclin D1 blocks the anti-proliferative function of RUNX3 by ... - OUCI

List of references · Malumbres, To cycle or not to cycle: a critical decision in cancer, Nat. · Hinds, Function of a human cyclin gene as an oncogene, Proc.

DNA damage signals from somatic uterine tissue arrest oogenesis ...

Using Caenorhabditis elegans, we show that DDR disruption, only in the uterus, when insulin/IGF-1 signaling (IIS) is low, arrests oogenesis in the pachytene ...

Expression of the cyclin-dependent kinase inhibitor Dacapo is ...

We also show that the oscillation of the Cyclin E and Dacapo proteins are tightly coupled during ovarian endocycles. Our results argue for a mechanism where ...

Non-canonical functions of cell cycle cyclins and cyclin-dependent ...

Some of these non-canonical functions are performed by cyclins or CDKs, independently of their respective cell cycle partners, suggesting that ...

Coordinating Proliferation, Polarity, and Cell Fate in the Drosophila ...

The fruit fly, Drosophila melanogaster, is a powerful experimental paradigm for oogenesis (Figures 1A,B). Oocytes arise from ovarian germline stem cells (GSCs), ...

THE ROLE OF CYCLIN B3 IN MAMMALIAN MEIOSIS

Although a canonical D-box motif is present in many proteins, different ... To eliminate the peptides observed from somatic cells, c-Kit mutant animal testis can ...

Noncanonical function of Capicua as a growth termination signal in ...

Here we show that Cic-L acts in two capacities during Drosophila oogenesis: 1) as a canonical sensor of RTK signaling in somatic follicle cells, ...

Cyclin-dependent kinases in C. elegans - Cell Division

Whereas Cdk1 and Cdk2 likely have a multitude of targets, only two major functions have been proposed for mammalian cyclin D-Cdk4/6 complexes.