A randomized controlled study on the effect of linaclotide with ...

A randomized controlled and long-term linaclotide study of irritable ...

This study suggests that a linaclotide dose of 0.5 mg is effective and safe for IBS-C patients in Japan.

580 g linaclotide with 2 L polyethylene glycol regimen can achieve the same bowel preparation effect with higher safety and patient satisfaction.

Pilot study on the effect of linaclotide in patients with chronic ...

In this pilot study, linaclotide treatment improved bowel habits and symptoms of patients with chronic constipation. Further randomized controlled trials ...

Efficacy For Patients With IBS-C | LINZESS® (linaclotide) | For HCPs

In a phase 3b trial, LINZESS improved overall abdominal symptoms (bloating, pain, discomfort)1,2. Improvement vs placebo was observed at week 1 and continued ...

Two Randomized Trials of Linaclotide for Chronic Constipation

We conducted two randomized, 12-week, multicenter, double-blind, parallel-group, placebo-controlled, dual-dose trials (Trials 303 and 01) ...

A randomized controlled and long‐term linaclotide study of irritable ...

This phase III trial in IBS-C patients in Japan revealed that 0.5 mg/d of linaclotide was effective on global improvement, complete spontaneous ...

Effect of Linaclotide on Quality of Life in Adults With Chronic ...

Linaclotide is a first-in-class, minimally absorbed guanylate cyclase type C receptor agonist that significantly improved bowel and abdominal symptoms and ...

Effects of Linaclotide in Patients With Irritable Bowel Syndrome With ...

MEDLINE, EMBASE, and the Cochrane central register of controlled trials were searched for randomized, placebo-controlled trials examining the ...

Linaclotide Reduced Response Time for Irritable Bowel Syndrome ...

A trial in patients with IBS-C, using a novel abdominal symptom scoring system derived from the average scores of multiple abdominal symptoms (pain, discomfort, ...

Effect of Linaclotide on Severe Abdominal Symptoms in Patients ...

In two phase 3 clinical trials, linaclotide has been shown to improve abdominal and bowel symptoms in patients with IBS-C. ... 9, 10 However, the efficacy of ...

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase ...

The results of this large, 12-week, placebo-controlled trial show that across a wide range of doses linaclotide statistically significantly improved multiple ...

(PDF) A randomized controlled and long-term linaclotide study of ...

The secondary endpoints included responder rates of SBM and abdominal pain/discomfort relief. Key Results Part 1: The responder rates for global improvement and ...

Effects of Linaclotide in Patients With Irritable Bowel Syndrome With ...

MEDLINE, EMBASE, and the Cochrane central register of controlled trials were searched for randomized, placebo-controlled trials examining the effect of ...

Linaclotide: A New Option for the Treatment of Irritable Bowel ...

Clinical trials have demonstrated that linaclotide is effective, safe and well tolerated in patients with CC and IBS-C. This review article ...

Impact of Linaclotide Treatment on Work Productivity and Activity ...

Results: Of the 1602 patients with IBS-C who were randomized in the 2 clinical trials, 1555 (97.1%) completed a baseline and at least 1 ...

The gut microbiota participates in the effect of linaclotide in patients ...

A 2018 phase III trial in China revealed that approximately 40% of patients did not respond to linaclotide treatment, potentially due to the ...

A 12-week, randomized, controlled trial with a 4-week ... - H1 Connect

This well conducted study demonstrates the efficacy of linaclotide in constipated patients, and the effect is maintained during the treatment period, reversing ...

Effect of linaclotide in irritable bowel syndrome with constipation ...

While linaclotide improved IBS-C symptoms in randomized controlled trials (RCTs), results vary among studies and the magnitude of benefit is unclear.

Pilot Study on the Effect of Linaclotide in Patients With Chronic ...

Clinical improvements were also demonstrated in abdominal discomfort, severity of constipation, and overall relief. Compared to placebo, ...

Effects of linaclotide in patients with irritable bowel syndrome with ...

For CC, on the basis of data from 3 trials of patients with CC, the RR for the primary end point (more than 3 CSBMs/week and an increase in 1 or more CSBM/week, ...