A retrospective analysis of the prognostic impact of KRAS G12D ...

The KRAS G12D mutation did not show a detrimental prognostic impact on PFS and OS compared to KRAS non-G12D mutations in patients with RAS-mutated mCRC.

Request PDF | A retrospective analysis of the prognostic impact of KRAS G12D mutation in patients with RAS -mutated metastatic colorectal cancer.

Impact of KRAS codon subtypes from a randomised phase II trial of ...

In a recently presented retrospective analysis, patients with KRAS G12V or G12A mutation-positive advanced NSCLC had longer PFS when treated ...

The prognostic impact of KRAS mutation in colorectal cancer patients

Conclusions: In addition to being a predictive biomarker, KRAS mutation is associated with inferior survival outcomes in patients receiving standard of care ...

KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced ...

Despite these discrepancies, the presence of a KRAS mutation seems to negatively affect survival, regardless of performing curative surgery or ...

SO-14 The prognostic impact of KRAS G12C mutation in patients ...

Patient characteristics were not significantly different between patients with the KRAS G12C and non-G12C mutations. At a median follow-up of 64.8 months, ...

The Prognostic Impact of KRAS G12C Mutation in Patients with ...

015) and overall survival (OS; median, 21.1 vs. 27.3 months; p = .015) than those with non-G12C mutations. Multivariate analysis also showed ...

The prognostic impact of KRAS, TP53, STK11 and KEAP1 mutations ...

We conducted a retrospective study in 100 patients with NSCLC and a known KRAS status. By accounting for different co-mutations, KRAS mutation was found to be ...

A retrospective analysis of the prognostic impact of KRAS G12D ...

Article "A retrospective analysis of the prognostic impact of KRAS G12D mutation in patients with metastatic colorectal cancer" Detailed information of the ...

Prognostic Value of KRAS Mutations in Colorectal Cancer Patients

Similar results were shown by Bai B, et al. in a total of 135 patients [20]. In the current study, the most frequent mutations were G12D (33.1%), G12V (21.2%) ...

Retrospective Comparative Analysis of KRAS G12C vs ... - UniCA IRIS

In pancreatic cancer, G12D mutation is the most frequent along with G12V,. G12C mutations are rarely seen, and G12R becomes also relatively ...

Assessing the prognostic value of KRAS mutation combined with ...

Our study confirmed staging and tumor size as prognostic factors. However, KRAS mutational status was not found to impact OS and there was no difference in the ...

The Prognostic Impact of KRAS, Its Codon and Amino Acid Specific ...

Across all stages, the 5-year overall survival (OS) is less than 15%. Even stage IA and IB non–small-cell lung cancer (NSCLC) has a relatively poor prognosis ...

Mutational variants of KRAS gene versus Wild-type KRAS in the ...

The impacts of KRAS gene status on prognosis and treatment choices in CC stage II-III are unstable; some studies indicate worse prognoses for ...

The impact of KRAS mutations on prognosis in surgically resected ...

KRAS mutations are common in colorectal cancer (CRC). The role of KRAS mutation status as a prognostic factor remains controversial, ...

Pooled Analysis of the Prognostic and Predictive Value of KRAS ...

Patients with KRAS MUT tumors derived no benefit from EGFR TKIs (OS HR = 1.13, CI: 0.85–1.51; progression-free survival HR = 1.02, CI: 0.76–1.36) ...

Prognostic and predictive effect of KRAS gene copy number and ...

Garassino et al. reported a decreased response to cisplatin but increased response to paclitaxel and pemetrexed in KRAS G12C mutated tumors, whereas, KRAS G12D ...

Prognostic impact of mutation profiling in patients with stage II and III ...

NRAS (codons 12, 13 and 61) mutations existed only in stage II colon cancer, 0.89% (2/224) tumors harbored a NRAS mutation, of which were G12D ...

Mutations matter: An observational study of the prognostic and ...

A large prospective study (n=440 KRAS-mutated CRC) conducted by Imamura et al. identified KRAS codon 12 mutations as predictive of poor ...

Clinicopathologic Characteristics and Outcomes for Patients With ...

11,17. The co-mutational profile, which has emerged as a considerable modulator of prognostic and predictive effect in KRAS-mutated NSCLC, is of particular.