A telomere|targeting drug depletes cancer initiating cells ...

A telomere-targeting drug depletes cancer initiating cells ... - Nature

This study underscores the immune-enhancing and metastasis-reducing effects of 6TdG, employing a range of complementary in vitro and in vivo SCLC preclinical ...

A telomere-targeting drug depletes cancer initiating cells and ...

This study underscores the immune-enhancing and metastasis-reducing effects of 6TdG, employing a range of complementary in vitro and in vivo SCLC preclinical ...

(PDF) A telomere-targeting drug depletes cancer initiating cells and ...

6-thio-2-deoxyguanine(6T-dG) is a novel telomere-specific nucleoside precursor ... [Show full abstract] recognized by telomerase. It is ...

A telomere-targeting drug depletes cancer initiating cells a

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer. Author & abstract; Download; 1 Reference ...

MAIA Biotechnology Announces Publication in Nature ...

Nature Communications, volume 15, article number: 672 (2024), “A telomere-targeting drug depletes cancer initiating cells and promotes anti- ...

MAIA Biotechnology Announces Publication in Nature ... - BioSpace

Nature Communications, volume 15, article number: 672 (2024), “A telomere-targeting drug depletes cancer initiating cells and promotes anti- ...

Targeting telomerase-expressing cancer cells - PMC - NCBI

The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res. 2010;70:9494–504. [PubMed] [Google ...

The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in ...

In vitro treatment of tumor cell lines with imetelstat results in progressive telomere shortening leading to cell senescence or apoptosis (18, ...

A telomere-targeting drug depletes cancer initiating cells and ... - OUCI

AbstractThere are few effective treatments for small cell lung cancer (SCLC) underscoring the need for innovative therapeutic approaches.

Andres F. Cardona on X: "A telomere-targeting drug depletes cancer ...

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer ...

Combining old and new concepts in targeting telomerase for cancer ...

This concept turned out to be wrong later as the used cell culture medium in these experiments continuously reseeded fetal cells. It initiated, ...

A Telomere-Targeting Drug Depletes Cancer Initiating Cells and ...

[Nature Communications] Using preclinical mouse and human derived models, investigators found low intermittent doses of ...

Telomere and Telomerase Therapeutics in Cancer - MDPI

Drug resistance and tumor progression have been attributed to subpopulation of cancer cells, termed cancer stem cells (CSC), and telomerase has been implicated ...

Cancer stem cells articles within Nature Communications

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer ... Therapeutic options for small cell lung ...

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

... telomerase-positive cancer cells, could initiate rapid DNA damage for innate sensing. ... cell lung cancer targeted therapy and chemotherapy ...

Telomerase-targeted therapies in myeloid malignancies

In vitro, IME has been shown to inhibit the proliferation of a variety of tumor cell lines69,70 and deplete CD34+ myelofibrosis (MF) HSCs/ ...

Novel anticancer therapeutics targeting telomerase

... telomere and telomerase based cancer therapeutics ... The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines.

MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative ...

A natural product described in this study may offer an opportunity to selectively kill drug-resistant cancer stemlike cells in triple-negative breast.

Telomerase Targeted Therapy in Cancer and Cancer Stem Cells

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. · Medicine, Biology. Genes & development · 1999.

In perspective: An update on telomere targeting in cancer - OUCI

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer. Buse Eglenen-Polat, Ryan R. Kowash ...