A unified approach to dissecting biphasic responses in cell signaling

This study presents a useful mathematical analysis of different signaling networks in an attempt to provide general rules that give rise to biphasic responses.

Biphasic responses are encountered at all levels in biological systems. At the cellular level, biphasic dose-responses are widely ...

A unified approach to dissecting biphasic responses in cell signaling

In all cases, the presence of biphasic responses (or specifically the onset of biphasic responses, i.e. biphasic peak) is shown by a curve involving two ...

A unified approach to dissecting biphasic responses in cell signaling

In-built competing effects are present at different levels in signaling networks, starting from basic biochemical building blocks to the ...

Biphasic responses in cell signalling: A unified approach - bioRxiv

Biphasic responses (both steady state dose responses and dynamic responses) have been recorded all across the landscape of cellular signaling ...

Biphasic responses in cell signalling: A unified approach - bioRxiv

At the cellular level, biphasic dose-responses are widely encountered in cell signalling and post-translational modification systems and ...

Biphasic responses in cell signalling: A unified approach

Biphasic responses are encountered at all levels in biological systems. At the cellular level, biphasic dose-responses are widely ...

A unified approach to dissecting biphasic responses in cell signaling

Author response: A unified approach to dissecting biphasic responses in cell signaling release_tuiwfglzfvg2dmr2azhw7ibeae ... Released as a peer_review by eLife ...

A unified approach to dissecting biphasic responses in cell signaling

Author response: A unified approach to dissecting biphasic responses in cell signaling release_tuiwfglzfvg2dmr2azhw7ibeae · "Save Paper Now".

Request a detailed protocol

... to request. Modeling biphasic interactions between nodes in a network. Research article. A unified approach to dissecting biphasic responses in cell signaling

Schematic of sigmoidal (A) and biphasic (B) response. - ResearchGate

Biphasic responses are encountered at all levels in biological systems. At the cellular level, biphasic dose-responses are widely encountered in cell signalling ...

J Krishnan Publications | Imperial College London

A unified approach to dissecting biphasic responses in cell signaling. 6 Dec 2023ELIFE13:32 pageseLIFE SCIENCES PUBL LTD. Co-authors Ramesh V, Krishnan J. View ...

Biphasic responses in multi-site phosphorylation systems - Journals

This provides both a consolidated understanding of how and under what conditions biphasic responses are obtained in multi-site phosphorylation ...

The biphasic behavior of incoherent feed-forward loops in ...

A unified approach to dissecting biphasic responses in cell signaling · Vaidhiswaran RameshJ. Krishnan. Biology, Computer Science. eLife. 2023. TLDR. A unified ...

Effects of multiple enzyme–substrate interactions in basic units of ...

A unified approach to dissecting biphasic responses in cell signaling. Vaidhiswaran Ramesh, J Krishnan. https://doi.org/10.7554/elife.86520 ·. 2023, eLife.

Biphasic Regulation of Transcription Factor Nuclear Factor-κB ...

... signals in endothelial cells by a pathway involving protein ... A unified approach to dissecting biphasic responses in cell signaling, eLife, 12, (2023).

Dissecting the Essence of Calcium Signaling Network as ... - Frontiers

The spike in the Ca2+-gated channel activates calcium-binding protein (CBP) SOS3 through myristoylation, a post-translational modification of SOS3, to mediate ...

The transcription factor unc-130/FOXD3/4 contributes to the biphasic ...

We provide the first evidence for a biphasic neural response of AIBs: calcium decreases during osmotic stimulation followed by a calcium ...

tunable components of biological signaling circuits

According to our model, linear patterns of phosphorylation along disordered protein segments determine the signal-response function of a ...

Cell Signaling – Fundamentals of Cell Biology

This signal is received by the cell. This will require a receptor to recognize the signal and respond to it. Most often the receptor is at the cell surface, ...