A2A Adenosine Receptor

Adenosine A2A receptor ... The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.

Adenosine A2A Receptor - an overview | ScienceDirect Topics

Adenosine A2A Receptor ... Adenosine A2A Receptor is a subtype of adenosine receptors that is Gs-protein-coupled and can increase intracellular cAMP levels, ...

135 - Gene ResultADORA2A adenosine A2a receptor [ (human)]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided ...

Human Adenosine A2A Receptor: Molecular Mechanism ... - Frontiers

In this review we analyze the structural data reported for A 2A R that described for the first time the binding of mode of antagonists.

Adenosine A2A Receptors in Psychopharmacology: Modulators of ...

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting a wide range of neuropsychiatric functions by interacting with and ...

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

This review will discuss the role of the adenosine-A2AR pathway in the tumor microenvironment and summarize recent advances of A2AR-cancer related studies.

The caffeine-binding adenosine A2A receptor induces age-like HPA ...

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), ...

p29274 · aa2ar_human - UniProt

Adenosine receptor A2a. Gene. ADORA2A. Status. UniProtKB reviewed (Swiss-Prot). Organism. Homo sapiens (Human). Amino acids. 412 (go to sequence). Protein ...

Adenosine A2A Receptor as a Drug Discovery Target

Following the discovery of adenosine, almost a century of intense research on adenosine receptors has led to the selection of the adenosine A2A receptor as a ...

A2A adenosine receptor protects tumors from antitumor T cells - PNAS

We hypothesized that A2AR also protects cancerous tissues by inhibiting incoming antitumor T lymphocytes. Here we confirm this hypothesis.

Single-molecule visualization of human A 2A adenosine receptor ...

et al. Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. Nat. Commun. 9, ...

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite ...

A 2A receptor - IUPHAR/BPS Guide to PHARMACOLOGY

adenosine A2a receptor, 43,72,108. Mouse, 7, 410, 10 C1, Adora2a, adenosine A2a receptor, 85. Rat, 7, 410, 20p12, Adora2a, adenosine A2a receptor, 22. Previous ...

A2A adenosine receptor functional states characterized by 19F-NMR

We use 19 F-NMR to characterize ensembles of different, simultaneously populated conformations of the human A 2A adenosine receptor in function-related ...

Adenosine A2A Antagonists | Parkinson's Foundation

The basal ganglia — a brain circuit group that plays a role in Parkinson's disease (PD) symptoms — has adenosine A2A receptors located next to dopamine ...

How do adenosine A2A receptors regulate motor function?

This review addresses how adenosine A 2A receptors are involved with the control of motor function via the basal ganglia-thalamocortical circuit.

ADORA2A Gene - GeneCards | AA2AR Protein

Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A ...

Structure-Based Discovery of A2A Adenosine Receptor Ligands

Characterization of the adenosine A2 receptor has been limited due to the lack of available ligands which have high affinity and selectivity for ...

Adenosine receptor - Wikipedia

The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand.

Lessons from the A2A Adenosine Receptor Antagonist–Enabled ...

Fong and colleagues describe the encouraging observations of tumor regression, disease control, and survival of patients with otherwise refractory renal cell ...