Acquisition of high|level chromosomal instability is associated with ...

Acquisition of high-level chromosomal instability is associated with ...

Whereas two key steps in cervical carcinogenesis are integration of high-risk human papillomavirus (HR-HPV) and acquisition of an unstable host genome, ...

Acquisition of High-Level Chromosomal Instability Is Associated with ...

Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical Keratinocytes · Split-Screen ...

Acquisition of High-Level Chromosomal Instability Is Associated with ...

Acquisition of High-Level Chromosomal Instability Is Associated with Integration of. Human Papillomavirus Type 16 in Cervical Keratinocytes.

Acquisition of chromosome instability is a mechanism to evade ...

Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically ...

Acquisition of chromosome instability is a mechanism to evade ...

Chromosomal Instability is a mechanism to circumvent oncogene addiction. · Genetic alterations driving resistance were most probably acquired ...

An acquired high-risk chromosome instability phenotype in multiple ...

Patients with multiple myeloma (MM) accumulate adverse copy number aberrations (CNAs), gains of 1q21, and 17p deletions during disease ...

The Multifaceted Role of Chromosomal Instability in Cancer and Its ...

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance.

Chromosomal instability accelerates the evolution of resistance to ...

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically antagonizes cellular fitness.

The two sides of chromosomal instability: drivers and brakes in cancer

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to ...

Chromosomal instability and acquired drug resistance in multiple ...

Chromosomal instability (CIN) is an important hallmark of human cancer. CIN not only contributes to all stages of tumor development (initiation, ...

The emerging links between chromosomal instability (CIN ...

It is known that circulating tumour cells can have a high level of CIN [218], but its implications in immune evasion have not been extensively ...

Chromosome instability is prevalent and dynamic in high-grade ...

Chromosome instability (CIN; an increased rate of chromosome gains and losses) is a form of genome instability that is commonly associated with ...

Examining the link between chromosomal instability and aneuploidy ...

... high rates of chromosome missegregation in a phenomenon called chromosomal instability (CIN) ... associated with defects in microtubule ...

Chromosomal Instability - an overview | ScienceDirect Topics

The process of CIN is also associated with an increase in the formation of micronuclei in cancer cells.34,35 Rupture of micronuclei liberates DNA into the ...

The Chromosomal Instability Pathway in Colon Cancer

The acquisition of genomic instability is a crucial feature in tumor ... cells with a high level of stress, the interactions between. MDM2, MDM4, and ...

Chromosomal instability accelerates the evolution of resistance to ...

Studies in yeast have previously linked the acquisition of aneu- ploidy ... high-FGA status was significantly associated with disease pro-.

Suppression of chromosome instability limits acquired drug resistance

Numerical chromosome instability, or nCIN, defined as the high frequency of whole chromosome gains and losses, is prevalent in many solid tumors ...

Disentangling the roles of aneuploidy, chromosomal instability and ...

Aneuploidy, CIN and ITH have each been individually associated with poor prognosis in cancer, and a wealth of evidence suggests they contribute, ...

Quantifying chromosomal instability from intratumoral karyotype ...

Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal mitotic segregation—is a hallmark of cancer that drives ...

Multi-Layered Cancer Chromosomal Instability Phenotype - Frontiers

Whole-chromosomal instability (W-CIN) – unequal chromosome distribution during cell division – is a characteristic feature of a majority of cancer cells ...