Actin Filaments A Target for Redox Regulation

Actin filaments-A target for redox regulation - PubMed

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have ...

Actin filaments – a target for redox regulation - PMC - NCBI

Both in vitro and in vivo studies have revealed that the cysteine residues on actin are highly susceptible to Redox intermediates – including ...

Actin filaments—A target for redox regulation - Wiley Online Library

The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. Free ...

Actin filaments-A target for redox regulation - University of Rochester

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have ...

(PDF) Actin filaments-A target for redox regulation - ResearchGate

In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular ...

Actin filaments-A target for redox regulation - Prairie State College

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have ...

Redox Regulation of the Actin Cytoskeleton in Cell Migration and ...

MICAL1 specifically mediates oxidation of F-actin, which enhances the binding of cofilin to filaments. This, in turn, increases actin filament severing by ...

Actin filaments—A target for redox regulation – Fingerprint ...

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Oxidation and reduction of actin: Origin, impact in vitro and ...

We show that the regulated balance of oxidation and reduction of key actin amino acid residues contributes to the control of actin filament polymerization and ...

Actin Methionine Oxidation: The Next Level Of Dynamic Regulation

Recent studies suggest that MICAL regulation of actin may be important for many actin-dependent cellular processes, and one must wonder how pervasive this redox ...

Reciprocal regulation of actin filaments and cellular metabolism

For cells to adhere, migrate and proliferate, remodeling of the actin cytoskeleton is required. This process consumes a large amount of ATP while having an ...

Control of actin polymerization via reactive oxygen species ...

It is known that actin and other actin-binding proteins are targets for reactive oxygen species (ROS), indicating that ROS affects cells through ...

Catastrophic disassembly of actin filaments via Mical-mediated ...

Actin filament assembly and disassembly are vital for cell functions. MICAL Redox enzymes are important post-translational effectors of ...

The MICAL and SelR/MsrB Reversible Redox Actin Regulatory ...

A) The MICAL family of from publication: Actin filaments-A target for redox regulation: F-Actin as a Target of Redox Signaling | Actin and its ability to ...

Redox regulation of the actin cytoskeleton and its role in the ...

438 References · Actin filaments—A target for redox regulation · Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for ...

Essential for Protein Regulation - Cytoskeleton, Inc.

Further investigation showed that H2O2- induced oxidation of actin initially targeted Cys374, but also targeted ... Actin filaments-A target for redox regulation.

Emerging roles of MICAL family proteins – from actin oxidation to ...

MICAL binds to F-actin and oxidizes the actin filament. Actin oxidation by MICAL weakens longitudinal interactions between actin subunits within ...

Regulating the actin cytoskeleton by controlling its oxidation - ANR

Key physiological functions, such as cell division, migration and morphogenesis, rely on proper regulation of actin filament assembly and disassembly.

Direct redox regulation of F-actin ... | Article | H1 Connect

... actin filament disassembly by the cytosolic, multi-domain redox enzyme Mical. Mical, a member of the flavoprotein monooxygenase family of redox enzymes, was ...

Redox Regulation of β-Actin during Integrin-mediated Cell Adhesion

Actin oxidation takes place via the formation of a mixed disulfide between cysteine 374 and glutathione; this modification is essential for spreading and for ...