Adenosine|A2A Receptor Pathway in Cancer Immunotherapy

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, ...

CD39/CD73/A2AR pathway and cancer immunotherapy

Adenosine-A2AR pathway could inhibit T-lymphocyte proliferation, activation, and cytokine production, leading to polarization of ...

Next steps for clinical translation of adenosine pathway inhibition in ...

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), ...

Targeting adenosine for cancer immunotherapy

The A2a and A2b receptors are G-protein coupled stimulatory pathways that are upregulated in response to immune cell activation. Upon engagement of the A2a or ...

Adenosine in cancer immunotherapy: Taking off on a new plane

Adenosine extracellular (eADO) activates cellular downstream signaling pathways by binding to G protein-coupled adenosine receptors A1, A2a, A2b, and A3. Both ...

Lessons from the A2A Adenosine Receptor Antagonist–Enabled ...

Lessons from the A2A Adenosine Receptor Antagonist–Enabled Tumor Regression and Survival in Patients with Treatment-Refractory Renal Cell Cancer.

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell ...

Along with blocking adenosine production with small molecules or mAbs, another approach to inhibit adenosine-induced signaling is to directly block binding to ...

Role of adenosine A2a receptor in cancers and autoimmune diseases

The combination of adenosine and A2AR can increase the concentration of cAMP and activate a series of downstream signaling pathways, and further ...

Blockade of adenosine A2A receptor enhances CD8+ T cells ...

Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor ... adenosine-A2A adenosine receptor pathway.

A2A adenosine receptor protects tumors from antitumor T cells - PNAS

We propose to target the hypoxia→adenosine→A2AR pathway as a cancer immunotherapy strategy to prevent the inhibition of antitumor T cells in the ...

Adenosine A2a receptor inhibition increases the anti-tumor efficacy ...

The combination of an A2aR inhibitor and anti-PD1 treatment had potent anti-tumor effects in two murine models of orthotopic liver cancer.

Targeting the Adenosine A2A Receptor as a Novel Therapeutic ...

Reportedly, the activation of the A2AR downstream pathway in tumor cells results in the downregulation of the immune system. Currently, increasing numbers of ...

Inhibition of the Adenosine Pathway to Potentiate Cancer ...

One such mechanism of immunosuppression is adenosinergic signaling within the tumor microenvironment. We provide an overview of the current status of clinical ...

Adenosine 2A Receptor Blockade as an Immunotherapy for ...

Accumulation of the nucleoside adenosine in the tumor microenvironment has been shown to inhibit the antitumor function of various immune cells, including ...

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor ...

An adenosine 2A receptor antagonist, as enhanced by blockade of TIM3, slowed tumor growth in vivo. Engagement of the adenosine 2A receptor and ...

Targeting Immunosuppressive Adenosine Signaling: A Review of ...

Adenosine accumulated in the TME exerts its effects on a variety of cell types by binding to A1, A2A, A2B, and A3 receptors. Signaling through ...

Adenosine Blockage in Tumor Microenvironment and Improvement ...

It seems that targeting the adenosine pathway in combination with immunotherapy may lead to efficient antitumor response. In this review, we ...

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

the ATP-adenosine immune-checkpoint pathway for cancer immunotherapy. The directional manipulation of eN/CD73 activity and adenosi- nergic ...

Adenosine interaction with adenosine receptor A2a promotes gastric ...

A2aR expression on GC cells promoted metastasis in vivo. The PI3K-AKT-mTOR signaling pathway was involved in adenosine-stimulated GC cell ...

[PDF] A2A adenosine receptor protects tumors from antitumor T cells

910 Citations · Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor · Adenosine-A2A Receptor Pathway in Cancer Immunotherapy · Hypoxia- ...