Adenosine A2A Receptor

Adenosine A2A receptor ... The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.

135 - Gene ResultADORA2A adenosine A2a receptor [ (human)]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided ...

Adenosine A2A Receptor - an overview | ScienceDirect Topics

Adenosine A2A Receptor ... Adenosine A2A Receptor is a subtype of adenosine receptors that is Gs-protein-coupled and can increase intracellular cAMP levels, ...

Human Adenosine A2A Receptor: Molecular Mechanism ... - Frontiers

In this review we analyze the structural data reported for A 2A R that described for the first time the binding of mode of antagonists.

Adenosine A2A Receptors in Psychopharmacology: Modulators of ...

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting a wide range of neuropsychiatric functions by interacting with and ...

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

This review will discuss the role of the adenosine-A2AR pathway in the tumor microenvironment and summarize recent advances of A2AR-cancer related studies.

The caffeine-binding adenosine A2A receptor induces age-like HPA ...

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), ...

Adenosine A2A Receptor as a Drug Discovery Target

Following the discovery of adenosine, almost a century of intense research on adenosine receptors has led to the selection of the adenosine A2A receptor as a ...

p29274 · aa2ar_human - UniProt

Adenosine receptor A2a. Gene. ADORA2A. Status. UniProtKB reviewed (Swiss-Prot). Organism. Homo sapiens (Human). Amino acids. 412 (go to sequence). Protein ...

Adenosine A2A Antagonists | Parkinson's Foundation

The basal ganglia — a brain circuit group that plays a role in Parkinson's disease (PD) symptoms — has adenosine A2A receptors located next to dopamine ...

Adenosine A2a Receptor - an overview | ScienceDirect Topics

The adenosine A2a receptors belong to a family of seven transmembrane G-protein-coupled receptors (GPCRs) and comprise of four subtypes (A1, A2a, A2b, and A3).

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite ...

Endothelial adenosine A2a receptor-mediated glycolysis is essential ...

Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including ischemic ...

Definition of adenosine A2A receptor antagonist NIR178 - NCI Drug ...

Upon administration, A2AR antagonist NIR178 selectively binds to and inhibits A2AR expressed on T lymphocytes. This prevents tumor-released adenosine from ...

A 2A receptor - IUPHAR/BPS Guide to PHARMACOLOGY

adenosine A2a receptor, 43,72,108. Mouse, 7, 410, 10 C1, Adora2a, adenosine A2a receptor, 85. Rat, 7, 410, 20p12, Adora2a, adenosine A2a receptor, 22. Previous ...

Retrograde adenosine/A2A receptor signaling facilitates excitatory ...

We identified adenosine/A 2A receptor (A 2A R) as a retrograde signaling pathway underlying presynaptic long-term potentiation (LTP) at a hippocampal ...

Dual roles of the adenosine A2a receptor in autoimmune ...

A2aR activation exerts a complex pattern in chronic autoimmune neurodegeneration: while providing anti-inflammatory effects on T cells and thus ...

Adenosine A2A receptor (IPR001513) - InterPro entry - EMBL-EBI

A2A receptors have a limited distribution in the brain and are found in the striatum, olfactory tubercle and nucleus accumbens. In the periphery, A2 receptors ...

Crystal structure of the adenosine A2A receptor bound to an ... - PNAS

Here we report the crystal structure of A 2A receptor bound to compound 1 (Cmpd-1), a novel A 2A R/N-methyl d-aspartate receptor subtype 2B (NR2B) dual ...

Adenosine A2a Receptor Agonists Products - R&D Systems

The activity of ADORA2A, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase.