Adenosine A2A receptor as potential therapeutic target in ...

Adenosine A2A receptor as potential therapeutic target in ... - PubMed

Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that regulates several important functions in the central nervous system.

In this review we will recapitulate and discuss the most relevant studies on the role of A 2A Rs in neurodegenerative, neurodevelopmental and psychiatric ...

The Pharmacological Potential of Adenosine A2A Receptor ...

The adenosine A 2A receptor subtype is recognized as a non-dopaminergic pharmacological target for the treatment of neurodegenerative ...

A2A Adenosine Receptor: A Possible Therapeutic Target for ... - MDPI

The A2A adenosine receptor, a member of the P1 purinergic receptor family, plays a crucial role in the pathophysiology of different neurodegenerative ...

Adenosine A2A receptor as potential therapeutic target in ...

[Display omitted] Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that regulates several important functions in the central nervous system.

The adenosine A2A receptor is a therapeutic target in neurological ...

There is a pending issue, namely, how to demonstrate the neuroprotective potential of A2AR antagonists that would lead to delay neurodegenerative disease ...

Targeting the Adenosine A2A Receptor as a Novel Therapeutic ...

The adenosine A2A receptor (A2AR) is one novel drug target that has been drawing attention. Reportedly, the activation of the A2AR downstream pathway in tumor ...

A2A adenosine receptor: a novel therapeutic target in renal disease

This review summarizes present knowledge on the characteristics of one subtype, the A2A adenosine receptor (A2A-AR) and its potential role in treating and ...

Adenosine A 2A receptor as a potential target for improving cancer ...

The adenosine nucleoside performs a wide range of actions on various human tissues by activating four cell surface receptors. Adenosine A2A ...

Adenosine A2A receptor as potential therapeutic target in ...

Abstract. Adenosine A2A receptor (A2AR) is a G-protein coupled receptor that regulates several important functions in the central nervous system. Large amount ...

Potential Therapeutic Applications of Adenosine A2A Receptor ...

Adenosine A2A receptors (A2ARs) are highly expressed in the human striatum, and at lower densities in the cerebral cortex, the hippocampus, ...

Targeting adenosine for cancer immunotherapy

Hypoxia, high cell turnover, and expression of CD39 and CD73 are important factors in adenosine production. Adenosine signaling through the A2a receptor ...

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

In addition, it is encouraging that A2AR blockade combined with CAR T cells therapy showed better anti-tumor efficacy. Therefore, this review ...

Adenosine A2A Receptor as a Potential Drug Target - Eurekaselect

Abstract. Adenosine receptors (ARs) are a class of G-protein coupled receptors (GPCRs) that are activated by the endogenous substance adenosine. ARs are ...

Role of adenosine A2a receptor in cancers and autoimmune diseases

A2AR is expressed on most inflammatory cells, indicating that A2AR has great potential as a therapeutic target for rheumatoid arthritis and ...

The adenosine A2A receptor is a therapeutic target in neurological ...

In addition, A2AR antagonists and, eventually, dual A2A/A2B receptor antagonists have potential in the treatment of heart arrythmias and cancer. If adequate ...

Adenosine A2A receptor as potential therapeutic target in ... - OUCI

Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders ... Authors: Maria Rosaria Domenici; Antonella Ferrante; Alberto Martire ...

Potential Therapeutic Interest of Adenosine A2A Receptors in ...

This makes A2A receptors particularly attractive targets to manage psychiatric disorders since adenosine may act as go-between glutamate and dopamine, two ...

Crystal structure of the adenosine A2A receptor bound to an ... - PNAS

The A2AR has been an attractive drug target due to its role in cardiovascular and immune system function, as well as in the central nervous ...

Adenosine A2a receptor agonists as regulators of inflammation

Characterization of A2aR-induced signaling pathways will be useful for the development of novel therapeutic strategies in ...