Adenosine as a neuromodulator in neurological diseases

Adenosine as a neuromodulator in neurological diseases - PMC

Abstract. Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and inhibitory neurotransmission. The past few ...

Adenosine as a neuromodulator in neurological diseases - PubMed

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and inhibitory neurotransmission. The past few years brought a wealth ...

Adenosine as a neuromodulator in neurological diseases

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and inhibitory neurotransmission. The past few years brought a wealth ...

Adenosine receptors and brain diseases: Neuroprotection and ...

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the central nervous system. Its neuromodulatory role relies on a balanced ...

Emerging roles of dysregulated adenosine homeostasis in brain ...

Together, these studies highlight the critical roles of adenosine metabolism in maintaining appropriate brain functions in health and diseases ...

Adenosine as a modulator of brain activity - Rutgers University

The endogenous neuromodulator adenosine controls and integrates a wide range of brain functions ... neurological diseases. This review covers the upstream ...

Adenosine Neuromodulation and Neuroprotection - SpringerLink

Apart from this main physiological role, adenosine also plays a relevant role in controlling the demise of damage in noxious brain conditions. In fact, the ...

How does adenosine control neuronal dysfunction and ...

Although adenosine can fulfill different signaling roles in the brain, its best-established role is as a synaptic neuromodulator (Dunwiddie and ...

Adenosine as a neuromodulator in neurological diseases

G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological diseases. Using adenosine A(2) receptors (A(1)Rs) as paradigm of GPCRs, ...

Adenosine Receptors in Neuropsychiatric Disorders - MDPI

Adenosine exerts an important role in the modulation of central nervous system (CNS) activity. Through the interaction with four G-protein coupled receptor ...

Adenosine A2A Receptors as Biomarkers of Brain Diseases - Frontiers

Adenosine A2A Receptors in Brain Diseases ... Upon acute brain injury, probably best exemplified by an ischemic brain stroke, concurrent pharmacological and ...

Adenosine as a neuromodulator in neurological diseases

Related reading · Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors.

Research progress on adenosine in central nervous system diseases

Thus, the adenosine receptor balance theory is important for brain disease treatment. The concentration of adenosine can be increased by ...

The Role and Regulation of Adenosine in the Central Nervous System

Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Tonic activation of adenosine ...

Boison, D. Adenosine as a neuromodulator in neurological diseases ...

Request PDF | Boison, D. Adenosine as a neuromodulator in neurological diseases. Curr. Opin. Pharmacol. 8, 2-7 | Adenosine is a modulator of brain function ...

Adenosine A 2A receptor blockade attenuates excitotoxicity in rat ...

Adenosine and Brain Ischemia: Role of A 2A Receptors ... The neuromodulator adenosine is largely released during an ischemic episode and may activate four ...

Extracellular ATP/adenosine dynamics in the brain and its role in ...

... neuromodulators that regulate numerous neuronal functions in the ... adenosine signaling plays a pivotal role in the pathogenesis of neurological diseases.

Targeting Adenosine Receptors in Neurological Diseases

Adenosine plays a significant role in neurotransmission process by controlling the blood pressure, while adenosine triphosphate (ATP) acts as a ...

Neuroprotection by adenosine in the brain: From A1 receptor ...

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A1 receptors (A1Rs) and the less abundant, ...

Modulation of neuroimmunity by adenosine and its receptors

Adenosine is a pleiotropic bioactive with potent neuromodulatory properties. Due to its ability to easily cross the blood–brain barrier, it can act as a ...