Adenosine receptors and Huntington's disease

Adenosine receptors and Huntington's disease - PubMed

Adenosine regulates important pathophysiological functions via four distinct adenosine receptor subtypes (A1, A2A, A2B, and A3). The A1 and A2A adenosine ...

The Role of Adenosine Tone and Adenosine Receptors in ...

In a more recent study, we found that cerebral spinal fluid (CSF) adenosine levels were significantly lower in HD patients and CSF concentrations of ATP were ...

Adenosine receptors and Huntington's disease - The Lancet

Adenosine has neuroprotective potential in both acute and chronic neurological disorders such as stroke or Parkinson's disease.

Adenosine Receptors and Huntington's Disease - ScienceDirect.com

This review highlights the recent findings that delineate the roles of adenosine receptors in HD and discusses their potential for serving as drug targets and/ ...

Adenosine receptors and Huntington's disease - The Lancet

Moreover, these models also provide good evidence of a role for excitotoxicity and mitochondrial metabolic impairments in striatal neuronal death. Adenosine has ...

Adenosine receptors and Huntington's disease - ScienceDirect.com

The modulation of adenosine receptors to slow down the neurodegenerative process in HD has great therapeutic potential. However, further pharmacological work is ...

Elucidating the role of the A2A adenosine receptor in ...

In spite of the extensive efforts that have been devoted to the characterization of HD pathogenesis, no disease-modifying therapy for HD is currently available.

Divergent Effects of the Nonselective Adenosine Receptor ... - MDPI

There is a controversy about potentially positive or negative effects of caffeine consumption on onset and disease progression of neurodegenerative diseases ...

Adenosine Receptors in Huntington's Disease - SpringerLink

Adenosine receptors are involved in a number of processes critical for neuronal function and homeostasis, such as modulation of synaptic ...

The role of adenosine tone and adenosine receptors in Huntington's ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein.

Targeting ENT1 and adenosine tone for the treatment of ...

Adenosine homeostasis is abnormal in the striatum of a mouse model of Huntington's disease (R6/2). The levels of adenosine, adenine nucleotides and AMP/ATP ...

The Role of Adenosine Tone and Adenosine Receptors in ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein.

Adenosine receptors and Huntington's disease: - ProQuest

Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder, the progression of which cannot be prevented by any neuroprotective ...

Blockade of Striatal Adenosine A2A Receptor Reduces, through a ...

Together, these observations support the view that adenosine A2A receptor antagonists may possess neuroprotective effects in neurodegenerative ...

Adenosine Receptors and Huntington's Disease | Request PDF

The A1 and A2A adenosine receptors (A1R and A2AR) are major targets of caffeine and have been extensively investigated. Huntington's disease (HD) is a dominant ...

Adenosine receptors and Huntington's disease - Semantic Scholar

The Adenosine A1 Receptor Agonist Adenosine Amine Congener Exerts a Neuroprotective Effect against the Development of Striatal Lesions and Motor Impairments in ...

What Is the Role of Adenosine Tone and Adenosine Receptors in ...

Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder caused by a CAG mutation within the IT15 gene encoding ...

Purinergic Signaling in the Pathophysiology and Treatment of ...

The striatum has a high expression of adenosine A2A receptors, which are involved in the neurodegeneration observed in HD. The P2X7 and P2Y2 receptors may also ...

Adenosine Receptors and Huntington's Disease | CoLab

Adenosine regulates important pathophysiological functions via four distinct adenosine receptor subtypes (A1, A2A, A2B, and A3). The A1 and A2A adenosine ...

ALTERED EXPRESSION AND FUNCTIONALITY OF A2A ...

... adenosine receptors in the pathogenesis of neuronal disorders, including Huntington's disease. Huntington's disease is an inherited neurodegenerative ...