Adjuvant and neoadjuvant therapy for cutaneous melanoma

Outline · - Initial surgery, followed by adjuvant therapy · - BRAF wild-type tumors · Adjuvant nivolumab · Adjuvant pembrolizumab · Adjuvant ...

Neoadjuvant Therapy and the Melanoma Standard of Care

The goals of neoadjuvant therapy include increasing the antitumor immune response and shrinking the tumor. Different types of treatments can be ...

Adjuvant and Neoadjuvant Therapies in Cutaneous Melanoma

Melanoma is the most common cause of skin cancer-related death in the United States. Cutaneous melanoma is most prevalent in the head and neck.

Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in ...

Among patients with resectable stage III or IV melanoma, event-free survival was significantly longer among those who received pembrolizumab ...

Understanding How New Neoadjuvant and Adjuvant Therapy ...

The use of anti–PD-1 or BRAF-targeted therapy after a complete surgical resection of high-risk stage IIB, IIC, III, and IV melanoma has been ...

Adjuvant and Neoadjuvant Therapeutics for the Treatment ... - PubMed

Adjuvant therapy plays an integral role in the treatment algorithm for stage III and stage IV cutaneous melanoma.

Neoadjuvant Immunotherapy in Melanoma: The Paradigm Shift

Patients who received adjuvant therapy underwent surgery first followed by 18 doses of pembrolizumab at a dose of 200 mg every 3 weeks (n = 159) ...

Perioperative therapy of melanoma: Adjuvant or neoadjuvant ...

A new therapeutic strategy in locoregional advanced melanomas becomes a preoperative treatment to further increase of the cure rates and ...

Advances in Adjuvant Therapy For Cutaneous Melanoma

Recent advances in immunotherapy with antibody-based immune checkpoint blockade (ICB) and targeted kinase-directed small molecule therapies have transformed the ...

Perioperative therapy of melanoma: Adjuvant or neoadjuvant ...

Furthermore, melanoma patients who do not achieve a major pathological response to neoadjuvant immunotherapy still need adjuvant therapy. Thus, adjuvant therapy ...

Adjuvant and Neoadjuvant Therapy in High-Risk Stage III ...

1. Barker, C.A.. Adjuvant therapy in high-risk stage III cutaneous melanoma ; 2. Sloot, S. ∙ Zager, J.S. ∙ Kudchadkar, R.R. ... BRAF inhibition for advanced ...

Adjuvant and Neoadjuvant Therapeutics for the Treatment of ...

Adjuvant therapy is integral in the treatment of stage III and IV melanoma after surgical resection. · Trials for neoadjuvant therapeutics are ...

Adjuvant therapies for melanoma - DermNet

Adjuvant therapy is defined as a treatment given after the initial therapy. In the case of cutaneous melanoma, adjuvant therapy is a form of treatment ...

Multidisciplinary treatment strategies in high-risk resectable melanoma

In the ongoing OpACIN trial (Table 2), neoadjuvant ipilimumab (3 mg/kg) plus nivolumab (1 mg/kg) is administered either as 4 adjuvant courses after surgery, or ...

Adjuvant and Neoadjuvant Therapies in Cutaneous Melanoma

In 1975, the FDA approved the alkylating agent dacarbazine for treatment of patients with unresectable, R/M melanoma. Despite a considerable lack of efficacy in ...

Long-term outcomes to neoadjuvant pembrolizumab based on ...

This is a follow-up study of a previously published phase Ib clinical trial of 30 patients with resectable stage III/IV cutaneous melanoma who ...

Novel adjuvant options for cutaneous melanoma - Annals of Oncology

Randomized studies of patients with resected high-risk melanoma have shown that immunotherapy or targeted therapy improve recurrence-free survival compared ...

Neo-Adjuvant Therapy for Metastatic Melanoma - MDPI

Melanoma treatment is leading the neo-adjuvant systemic (NAS) therapy field. It is hypothesized that having the entire tumor in situ, with all of the ...

Adjuvant and Neoadjuvant Therapeutics for the Treatment of ...

Adjuvant therapy plays an integral role in the treatment algorithm for stage III and stage IV cutaneous melanoma. Current ongoing clinical trials are ...

Neoadjuvant Therapy and Adjuvant Therapy for Melanoma - YouTube

of skin cancer that develops in the cells that produce melanin, the pigment that gives skin its color. It is the most dangerous form of skin ...