Advances in the diagnosis and management of haemophagocytic ...

The diagnosis can be challenging due to overlapping signs and symptoms with other diseases. Therefore, early detection and prompt initiation of treatment is ...

Recent advances in the diagnosis and treatment of hemophagocytic ...

Key for a favorable prognosis is the rapid identification of an underlying genetic cause, which has been facilitated by recent immunological and genetic ...

Familial haemophagocytic lymphohistiocytosis: advances in the ...

The treatment involves initially the control of infectious triggers and of the immune dysregulation with chemotherapeutic regimens followed by definitive ...

Hemophagocytic lymphohistiocytosis: current treatment advances ...

The treatment of HLH is primarily divided into two phases: controlling excessive inflammation and replacing the defective immune system. The ...

Advances in Pathophysiology, Diagnosis, and Treatment

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disorder characterized by immune dysregulation, overwhelming immune activation, and ...

Recommendations for the management of hemophagocytic ...

Statement 6: HLH-94 treatment components, including etoposide, are highly effective in treating hyperinflammation in adults with HLH (Figure 1) ...

Recent advances in the treatment of hemophagocytic...

In this review, we discuss recent efforts to reduce the dose of etoposide and/or incorporate cytokine-targeted therapies for the treatment of HLH/MAS.

Current status of the diagnosis and treatment of hemophagocytic ...

Genetic alterations causing HLH, such as abnormalities of genes related to the inactivation of immune cells, have been discovered in adults. For ...

[PDF] Recent advances in the diagnosis and treatment of ...

Hemophagocytic lymphohistiocytosis: pathogenesis and treatment. · Medicine. Hematology. American Society of Hematology… · 2013.

Haemophagocytic syndromes: the importance of early diagnosis ...

Without proper treatment, HLH can be fatal. The risk of a rapid progression to multi-organ failure and central nervous system involvement leading to long-term ...

The 2022 EULAR/ACR points to consider at the early stages of ...

Several important collaborative efforts have shaped the current approach to the diagnosis and management of HLH and MAS. The Histiocyte Society, and later ...

Recommendations for the management of hemophagocytic ...

Treatment of malignancy-triggered HLH needs to balance HLH-specific and tumor-specific treatment. Corticosteroids are often used as first-line ...

Hemophagocytic Lymphohistiocytosis

Early recognition and assessment of potential causes of HLH is critical to improve survival. Urgent treatment is needed for immunosuppression ...

Macrophage activation syndrome in adults - Oxford Academic

In contrast to malignancy-associated HLH, the treatment approach is somewhat clearer for patients with MAS, where there is considerable overlap between the ...

Hemophagocytic lymphohistiocytosis: pathogenesis and treatment

Treatment of HLH aims at suppressing hypercytokinemia and eliminating the activated and infected cells. In genetic HLH, hematopoietic stem cell ...

Haemophagocytic lymphohistiocytosis (HLH) following allogeneic ...

The genetic basis of fHLH is increasingly well recognised and treatment outlined in the HLH-2004 protocol [2]. Emapalumab, a novel interferon-γ ...

Diagnosis and Management of Adult Malignancy-Associated ... - MDPI

Primary HLH without treatment is uniformly fatal [50], and prior to the advent of etoposide-based therapy, outcomes were dismal, with 5-year overall survival ( ...

Hemophagocytic Lymphohistiocytosis: An Update on Diagnosis and ...

Our article summarizes these new advances in the diagnosis of HLH and includes a review of clinical findings, updated understanding of the pathogenesis, and ...

Diagnosis and Management of Secondary HLH/MAS Following ...

Diagnosis and management of secondary HLH/MAS following HSCT and CAR-T cell therapy in adults; a review of the literature and a survey of practice within EBMT ...

Hemophagocytic lymphohistiocytosis and macrophage activation ...

Treatment of malignancy-associated hemophagocytic is similar to other forms of HLH, consisting of immunoglobulins, corticosteroids, and/or ...