Advantages of targeting the tumor immune microenvironment over ...

Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer ...

Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy.

Tumor microenvironment as a therapeutic target in cancer - PMC

There is a significant therapeutic advantage in targeting the TME compared with directly targeting cancer cells, because cancer cells are prone to drug ...

Therapeutic targeting of the tumor microenvironment: Cancer Cell

Thus, targeting certain chemokines and their receptors may reduce chronic inflammation in the primary tumor, while simultaneously preventing the development of ...

Targeting the tumor microenvironment: removing obstruction to ...

Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies ...

Tumor microenvironment as a therapeutic target in cancer

There is a significant therapeutic advantage in targeting the TME compared with directly targeting cancer cells, because cancer cells are prone to drug ...

Targeting the tumor microenvironment: Potential strategy for cancer ...

The significant abundance of TAMs in the TME across various cancer types highlights their critical role in shaping the tumor immune landscape through reciprocal ...

The future of cancer immunotherapy: microenvironment-targeting ...

T cell responses are heavily regulated to ensure balance between enabling immune reactivity to foreign antigens and safeguarding against ...

Advantages of targeting the tumor immune microenvironment ... - OUCI

Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anti-cancer immunity, which may result in immune checkpoint ...

Immunotherapy: Reshape the Tumor Immune Microenvironment

Introduction. The immune system can eliminate tumor cells through the cancer-immune cycle (1). This process is not sustained because tumors can gradually shape ...

Advantages of targeting the tumor immune microenvironment ... - Scilit

Based on their general targetability in clinical therapy, we believe that tumor immune microenvironment regulators are promising cancer ...

Advantages of targeting the tumor immune microenvironment over ...

Based on their general targetability in clinical therapy, we believe that tumor immune microenvironment regulators are promising cancer ...

Targets of tumor microenvironment for potential drug development

The immune system can identify, react to, and eliminate tumor cells. However, during the development of cancer, various cellular and molecular ...

Immune microenvironment modulation unmasks therapeutic benefit ...

Background Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T ...

The Tumor Microenvironment in the Response to Immune ... - Frontiers

The composition of the tumor microenvironment (TME) has been shown to influence response to immune checkpoint blockade (ICB). ICB takes advantage of immune cell ...

Tumor microenvironment: barrier or opportunity towards effective ...

Recent studies have shown that these specialized TME microenvironments and niches have potential to act as target of cancer therapy through ...

Targeting Tumor Microenvironment for Cancer Therapy - MDPI

The myeloid-derived suppressive cells (MDSCs) are important players in the immune response against tumors [23,79]. The elevated release of growth factors such ...

Reprogramming Tumor Immune Microenvironment (TIME) and ...

The tumor immune microenvironments (TIME) represent a complicated network of various tumor composites that suppress cancer immunity and lead to ...

Exploring and Targeting the Tumor Immune Microenvironment of ...

Specifically, we found that patients with tumors infiltrated by higher levels of cytotoxic lymphocytes had a better overall survival. Additionally, we found ...

Targeting the immune microenvironment in ovarian cancer therapy ...

The objective behind this strategy is to target the inhibitory signal that cancer cells use to suppress T-cell activity, thereby allowing the ...