Allosteric Modulation of the Pentameric Ligand|Gated Ion Channel ...

Allosteric regulation of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the binding of a ...

Allosteric Modulation of the Pentameric Ligand-Gated Ion Channel ...

Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are a class of ion channels involved in fast synaptic transmission in ...

Allosteric Modulation of the Pentameric Ligand-Gated Ion Channel ...

The family of pentameric ligand-gated ion channels or Cys-loop receptors is a class of ion channels involved in synaptic transmission in the ...

Structural basis for allosteric transitions of a multidomain pentameric ...

Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that mediate rapid electrochemical signal transduction in the animal nervous system ...

Structural basis for the modulation of pentameric ligand-gated ion ...

Pentameric ligand-gated ion channels (pLGICs) play a central role in synaptic communication and are implicated in a plethora of neurological ...

Un-gating and allosteric modulation of a pentameric ligand ... - PLOS

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding ...

3D structure and allosteric modulation of the transmembrane ...

Pentameric ligand-gated ion channels (pLGICs) are transmembrane protein complexes that mediate chemical communication between cells in both the central and ...

Allosteric regulation of pentameric ligand-gated ion channels - HAL

A cyan sphere shows the location of the allosteric Ca2+ binding site for the modulation of pLGICs by divalent cations. The coordinates of the ...

Open-channel structure of a pentameric ligand-gated ion ... - Nature

Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment.

Vestibular Modulation by Stimulant Derivatives in a Pentameric ...

Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) is critical to the action of neurotransmitters and many psychoactive ...

Allosteric modulation of ligand-gated ion channels - ScienceDirect

Following activation, LGICs open allowing an ion flux across the cell membrane. Depending upon the charge and concentration of ions, the flux can cause a ...

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets ...

Experimental data have shown that novel allosteric modulators targeting the excitatory nicotinic acetylcholine receptor, as well as the inhibitory GABAA and ...

Allosteric regulation of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the binding of a chemical ...

Allosteric Mechanisms of Anesthetic Modulation of Pentameric ...

Allosteric Mechanisms of Anesthetic Modulation of Pentameric Ligand-Gated Ion Channels. Host. Department of Biology. Description. Small-molecule modulators ...

Allosteric modulation of pentameric ligand-gated ion channels by ...

Pentameric ligand-gated ion channels (pLGICs) are key components of fast synaptic transmission and are targets of neuroactive drugs such as ...

Un-gating and allosteric modulation of a pentameric ligand-gated ...

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at syn- apses through the opening of an ion pore in response to the ...

3D structure and allosteric modulation of the transmembrane ...

Semantic Scholar extracted view of "3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels" by J.

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion ...

Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by cryo- ...

(PDF) Un-gating and allosteric modulation of a pentameric ligand ...

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response ...

Un-gating and allosteric modulation of a pentameric ligand-gated ...

Link to Pubmed [PMID] – 29069080. PLoS Comput. Biol. 2017 Oct;13(10):e1005784. Pentameric ligand-gated ion channels (pLGICs) mediate intercellular ...