Allosteric regulation of Arf GTPases and their GEFs at the membrane ...

Arf GTPases assemble protein complexes on membranes to carry out major functions in cellular traffic. An essential step is their activation by guanine ...

Arf GTPases assemble protein complexes on membranes to carry out major functions in cellular traffic. An essential step is their activation ...

ARF GTPases and their GEFs and GAPs: concepts and challenges

ARF family GTPases control key cellular processes, including bidirectional membrane ... allosteric activation of cytohesin family Arf GTPase ...

Control of cell signaling by Arf GTPases and their regulators

We also describe specific effects of an Arf GEFs and two subtypes of Arf GAPs on signaling. 2.1. Diverse Arf-regulated membrane traffic events contribute to Ras ...

Allosteric regulation of Arf GTPases and their GEFs at the membrane ...

Allosteric regulation of Arf GTPases and their GEFs at the membrane interface · List of references · Publications that cite this publication.

Allosteric Regulation of Small GTPases on Membranes - Cell Press

Lipidated small GTPases and their regulators assemble at the surface of membranes ... Arf GTPases and Brag2 in artificial membranes. We ...

The ARF GTPase regulatory network in collective invasion and ...

M. and. Cherfils. ,. J. (. 2016. ) Allosteric regulation of Arf GTPases and their GEFs at the membrane ...

Arf GTPases and their effectors: assembling multivalent membrane ...

Arf GTPases are major regulators of membrane traffic and organelle structure in eukaryotes where they recruit many different effectors.

Arf GTPase regulation through cascade mechanisms and positive ...

Golgi-localized large Arf GEFs are autoinhibited in solution. Their catalytic activity and membrane association are controlled by cooperative allosteric ...

ARF GTPases and their GEFs and GAPs: concepts and challenges

In this review, we summarize current knowledge of three protein families: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that activate ...

Multiple interactions between an Arf/GEF complex and ... - PNAS

Lipidated small GTPases and their regulators need to bind to membranes to propagate actions in the cell, but an integrated understanding of how the lipid ...

The HUS box is required for allosteric regulation of the Sec7 Arf-GEF

The Golgi complex is the central membrane and protein-sorting station in eukaryotic cells. Activation of Arf (ADP-ribosylation factor) GTPases is essential ...

(PDF) Allosteric Regulation of Arf GTPases and Their GEFs

Allosteric Regulation of Arf GTPases and Their GEFs at the Membrane Interface by Agata Nawrotek, Mahel Zeghouf, Jacqueline Cherfils published in.

Shared and specific functions of Arfs 1–5 at the Golgi revealed by ...

J. Cherfils . 2016 . Allosteric regulation of Arf GTPases and their GEFs at the membrane interface . Small GTPases. 7. : 283. –. 296 . https ...

ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking ...

ARFs on/off switch is tightly regulated by guanine nucleotide exchange factors (GEFs), that turn ARFs on and GTPase activating proteins (GAPs), ...

Allosteric properties of PH domains in Arf regulatory proteins

... membrane such that its interaction with Arf favors GTP hydrolysis. In line ... GEFs: structural basis for their activation of small GTP-binding proteins.

ARF family G proteins and their regulators: roles in membrane ...

c | ARF family G proteins undergo a cycle of GTP binding and hydrolysis, mediated by guanine nucleotide exchange factors (GEFs) and GTPase- ...

What are Arf GTPases? - Mechanobiology Institute - NUS

Donaldson JG, and Jackson CL. ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat. Rev ...

(PDF) ARF GTPases and their GEFs and GAPs - ResearchGate

ensure allosteric communication between the membrane- and the nucleotide-binding sites. GEFs, GAPs, and effectors generally bind to switch 1, ...

Regulation of Small GTPases by GEFs, GAPs, and GDIs

These concerted changes couple membrane recruitment of Arf family members to their activation by GDP/GTP exchange (reviewed in Ref. 223). This large structural ...