Allosteric regulation of pentameric ligand|gated ion channels

Allosteric regulation of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the binding of a ...

Allosteric regulation of pentameric ligand-gated ion channels - HAL

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective. Antoine Taly, Jérôme Hénin, Jean-Pierre ...

Structural basis for allosteric transitions of a multidomain pentameric ...

Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that mediate rapid electrochemical signal transduction in the animal nervous system ...

Allosteric regulation of pentameric ligand-gated ion channels - HAL

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the binding of a ...

Regulation of a pentameric ligand-gated ion channel by a ...

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from ...

A gating mechanism of pentameric ligand-gated ion channels - PNAS

Pentameric ligand-gated ion channels (pLGICs) control membrane conductance in living systems from bacteria to humans. ... The latter is initiated by the outward ...

Insights and Incongruities in Pentameric Ligand-gated Ion Channel ...

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in electrochemical signal transduction across evolution, ...

(PDF) Allosteric regulation of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the ...

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion ...

TRP channels are a superfamily of cation-selective channels that are implicated in many physiologic functions including temperature sensation and regulated by ...

Investigating allosteric regulation by membrane domains of two ...

Investigating allosteric regulation by membrane domains of two pentameric ligand-gated ion channels ; Nate Rogers · Department of Biophysics, ...

Un-gating and allosteric modulation of a pentameric ligand ... - PLOS

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding ...

Mutational analysis to explore long-range allosteric couplings ... - eLife

Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not ...

Open-channel structure of a pentameric ligand-gated ion ... - Nature

Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment.

Article Role of the Fourth Transmembrane α Helix in the Allosteric ...

The gating of pentameric ligand-gated ion channels is sensitive to a variety of allosteric modulators that act on structures peripheral to ...

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets ...

The ion fluxes through pLGICs generate transient changes in the membrane potential, allowing the dynamic control of the neuronal excitability. Recent structural ...

Allosteric regulation of pentameric ligand-gated ion channels: An ...

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the binding of a ...

Protein dynamics and the allosteric transitions of pentameric ...

Allosteric interactions between proteins and their regulatory ligands were initially defined as indirect interactions between topographically ...

Allosteric Activation and Modulation of Pentameric Ligand-gated Ion ...

Eukaryotic Cys-loop receptors control fast synaptic transmission and are important targets for various therapeutics, including general anesthetics.

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop ...

A new inventory and phylogenetic analysis of pLGIC genes across all kingdoms of life suggests new hypotheses on the evolutionary history of the superfamily, ...

Pentameric Ligand-Gated Ion Channels | Encyclopedia MDPI

Pentameric ligand-gated ion channels (pLGICs) mediate or modulate fast synaptic communication in the central and peripheral nervous systems.