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Altered pain responses in mice lacking α 1E subunit of the ...


Altered pain responses in mice lacking α 1E subunit of the voltage ...

We have recently identified that this suppression of pain response in sensitized B6 mice is opioid-independent but sensitive to serotonin receptor (5-HT2A/2C) ...

Altered pain responses in mice lacking α 1E subunit of the ... - PNAS

Furthermore, α1E−/− mice that had been presensitized with a visceral noxious conditioning stimulus showed increased responses to a somatic inflammatory pain, in ...

Altered pain responses in mice lacking alpha 1E subunit ... - PubMed

alpha(1E)+/- mice showed reduced response to visceral inflammatory pain, whereas alpha(1E)-/- mice showed apparently normal response compared ...

Altered pain responses in mice lacking 1E subunit of the ... - PNAS

Our strategy is to insert lacZ gene encoding ß-galactosidase (ß-gal) into the first exon of cacna1e encoding α1E subunit to disrupt the gene and, at the same ...

Altered pain responses in mice lacking α1E subunit of ...

Fingerprint. Dive into the research topics of 'Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel'.

Altered Nociceptive Response in Mice Deficient in the α1B Subunit ...

We performed several pain-related behavioral tests using the mutant mice. α1B-Deficient mice show reduced response to mechanical stimuli in the von Frey test ...

Altered pain responses in mice lacking α>1E> subunit of the voltage ...

Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel · Tokyo Medical and Dental University · Japan Science and Technology ...

Pain sensitivity in mice lacking the Cav2.1α1 subunit of P/Q-type ...

To address this issue, we have analyzed pain-related behavioral responses of null mutant mice for the CaV2.1α1 subunit of P/Q-type channels. Homozygous null ...

Suppression of inflammatory and neuropathic pain symptoms in ...

We report here that mice lacking N‐type VDCCs show suppressed responses to a painful stimulus that induces inflammation and show markedly reduced symptoms of ...

Mice lacking Kcns1 in peripheral neurons show increased... - PAIN

To investigate Kcns1 function specifically in the periphery, we generated transgenic mice in which the gene is deleted in all sensory neurons but retained in ...

Pain Perception in Mice Lacking the 3 Subunit of Voltage-activated ...

In sympathetic neurones of ß3-deficient mice, N- and L-type calcium channel currents are reduced, the activation of P/Q type calcium chan- nels is altered, and ...

Neuropathic pain develops normally in mice lacking both Nav1.7 ...

Two voltage gated sodium channel α-subunits, Nav1.7 and Nav1.8, are expressed at high levels in nociceptor terminals and have been ...

Attenuated pain responses in mice lacking Ca V 3.2 T-type channels

In acute mechanical, thermal and chemical pain tests, CaV3.2−/− mice showed decreased pain responses compared to wild-type mice. CaV3.2−/− mice ...

Calcium-Permeable Ion Channels in Pain Signaling

Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci USA 97: 6132–6137, 2000 ...

Markedly attenuated acute and chronic pain responses in mice ...

Therefore, we investigated the potential pronociceptive function of AC5 in nociception using recently developed AC5 knockout mice (AC5−/−). We ...

Pain persists in mice lacking both Substance P and CGRPα signaling

We therefore generated Tac1 and Calca double knockout (DKO) mice and assessed their behavior using a wide range of pain-relevant assays. As ...

Long-lasting reflexive and nonreflexive pain responses in two ...

Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia ...

α-Conotoxin Vc1.1 inhibits human dorsal root ganglion ... - Gut

1 inhibits mouse colonic nociceptors and also low-threshold distension-sensitive colonic afferents with greatest effect during chronic visceral hypersensitivity ...

RBRC04885

Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Saegusa H, Kurihara T, Zong S, Minowa O ...

Ion Channels Relevant to Pain - International Headache Society

tribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. ... Altered pain responses in mice lacking alpha 1E ...