Amplifying gene expression with RNA|targeted therapeutics

Amplifying gene expression with RNA-targeted therapeutics - Nature

This Review highlights emerging RNA-targeted therapeutics for gene activation, focusing on opportunities and challenges for translation to the clinic.

Amplifying gene expression with RNA-targeted therapeutics - PubMed

Many diseases are caused by insufficient expression of mutated genes and would benefit from increased expression of the corresponding ...

RNA-based therapeutics: an overview and prospectus - Nature

A Antisense oligonucleotides (ASOs) can modulate the target gene expression through two mechanisms. (①) In the occupancy-mediated degradation ...

Amplifying gene expression with RNA-targeted therapeutics - OUCI

Hsiao, J. et al. Upregulation of haploinsufficient gene expression in the brain by targeting a long non-coding RNA improves seizure phenotype in a model of ...

Harnessing synthetic biology for advancing RNA therapeutics and ...

... gene expression regulation, signal amplification, and logic operations. Unsurprisingly, these devices and circuits, with their ability ...

Our approach to nucleotide-based therapeutics - AstraZeneca

... expression of disease-causing genes, which can have potential therapeutic benefit. By targeting the underlying genetic ... Self-amplifying RNA (saRNA); More ...

Trans-amplifying RNA expressing functional miRNA mediates target ...

... gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplifying RNA (taRNA) ...

The Limitless Future of RNA Therapeutics - Frontiers

... RNA to downregulate the expression of a specific gene. Tomar et al. (2003) ... RNA therapeutics, messenger RNAs (mRNAs), self-amplifying mRNA. Citation ...

Advances in the delivery of RNA therapeutics - Genome Medicine

Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression ...

Andrés D. Klein LinkedIn'de: Amplifying gene expression with RNA ...

Are you interested in nucleic acid therapeutics? This review summarizes recent developments, including gene therapy, mRNA delivery, ...

Amplifying gene expression with RNA-targeted therapeutics - X-MOL

Amplifying gene expression with RNA-targeted therapeutics. Nat. Rev ... gene therapy can achieve the goal of increased protein expression ...

Modulating intracellular pathways to improve non-viral delivery of ...

... gene delivery, RNA therapeutics are predominantly formulated in non-viral delivery systems. ... Amplifying gene expression with RNA-targeted therapeutics. 2023, ...

Amplifying gene expression with RNA-targeted therapeutics

Many diseases are caused by insufficient expression of mutated genes and would benefit from increased expression of the corresponding protein.

Improvement of In Vivo Expression of Genes Delivered by Self ...

Amplification eventually leads to very high RNA copy numbers of up to 2 × 105 copies per cell. Thus, much lower amounts of saRNA compared to conventional mRNA ...

Targeting RNA for Drug Discovery - Promega Corporation

... gene expression from the same well during siRNA gene silencing. RNA-Protein Interactions. The interplay between RNA and RNA-binding proteins (RBPs) is ...

The value of RNA sequencing in drug discovery - Tempus

However, gene expression is dynamic and evolves as the tumor progresses, metastasizes, is exposed to therapy, and develops resistance. Fewer ...

Thierry Dorval on LinkedIn: Amplifying gene expression with RNA ...

Thierry Dorval's Post · Amplifying gene expression with RNA-targeted therapeutics - Nature Reviews Drug Discovery · More Relevant Posts · More from ...

Trans-amplifying RNA: Translational application in gene therapy

The SFV-replicase showed amplification of all evaluated alphavirus STRs, even demonstrating enhanced expression for all heterologous STRs except ...

Target RNA modification for epigenetic drug repositioning in ...

... gene amplification and advanced INSS stage (P < 0.05, Table 2). Table ... When genes are drug targets, their CNVs affected gene expression ...

RNA‐based medicine: from molecular mechanisms to therapy

While mRNA‐based protein replacement therapies allow temporary expression of a functional copy of a transcript, therapeutic genome editing ...