An aging|related immune landscape in the hematopoietic immune ...

We describe a hematopoietic immune map of the spleen and bone marrow of young and old mice using single-cell sequencing and flow cytometry techniques.

Overall, aging extensively alters the cellular composition and function of the HIS. These findings could potentially give high-dimensional ...

[PDF] An aging-related immune landscape in the hematopoietic ...

A hematopoietic immune map of the spleen and bone marrow of young and old mice is described to enable more accurate functional and developmental analyses as ...

(PDF) An aging-related immune landscape in the hematopoietic ...

PDF | Background Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall ...

Additional file 9 of An aging-related immune landscape in the ...

Additional file 9 of An aging-related immune landscape in the hematopoietic immune system · Jianjie Lv · Chun Zhang · Xiuxing Liu · Chenyang Gu · Yidan Liu · Yuehan ...

Additional file 10 of An aging-related immune landscape in the ...

posted on 2024-08-14, 04:44 authored by Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, ...

Abstract Background Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of ...

Immune ageing at single-cell resolution | Nature Reviews Immunology

Ageing leads to profound alterations in the immune system and increases susceptibility to some chronic, infectious and autoimmune diseases.

Hematopoietic Stem Cells and the Immune System in Development ...

However, with age, changes occur in the pool of HSCs that negatively affect haematopoiesis and the effectiveness of immunity. Niche aging and ...

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the ...

We also discuss how age-dependent alterations of the immune system lead to subclinical inflammatory states and how inflammatory signaling might be involved in ...

Hematopoietic aging promotes cancer by fueling IL-1 - Science

Notably, reconstituting old mice with a youthful immune system rescues their antitumor response and delays lung cancer progression. Hematopoietic aging enhances ...

Aging is associated with functional and molecular changes ... - Nature

Physiological aging of the hematopoietic system is associated with decreased competence of the immune system, onset of anemia, myeloid ...

Aging brain: exploring the interplay between bone marrow aging ...

These age-related shifts in the bone marrow microenvironment contribute to dysregulation of immune cell homeostasis and function, impacting ...

Molecular and cellular mechanisms of aging in hematopoietic stem ...

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning.

Review Targeting immune dysfunction in aging - ScienceDirect.com

B cells are essential for adaptive immunity through their antigen presenting and antibody production capacities. It is widely accepted that during aging B cells ...

Exercise reprograms the inflammatory landscape of multiple stem ...

Significant upregulation of ribosomal genes with age was found in the majority of SVZ cells and in the majority of non-immune cells in skeletal ...

Rebuilding and rebooting immunity with stem cells - Cell Press

Immune regeneration therapies present exciting strategies to address age-related diseases by rebooting the host's primary lymphoid tissues or rebuilding the ...

Aging of hematopoietic stem cells | Blood - ASH Publications

As referred to previously, clonal hematopoiesis is a frequent event in elderly people. The first studies that reported on this phenomenon assessed whether X- ...

Impacts of aging on immunity and hematopoiesis. During aging

These hematopoietic changes result in increased dependence of the immune system on innate rather than acquired immunity, with an enhanced basal level of ...

Volume 21, issue 1 | Immunity & Ageing - SpringerLink

Volume 21, issue 1 articles listing for Immunity & Ageing. ... An aging-related immune landscape in the hematopoietic immune system. Authors ...