An argument for broad use of high efficacy treatments in early ...

Initiating higher efficacy treatments early is the best way to achieve the best possible long-term outcomes for people with MS.

(PDF) An argument for broad use of high efficacy treatments in early ...

At 4 years of follow-up, the probabilities of a 6-month confirmed Expanded Disability Status Scale (EDSS) score worsening were 16.7% (95% ...

The Argument for High-Efficacy Early Treatment for Pediatric-Onset ...

We introduce a new treatment approach, the “high-efficacy early treatment”, or HEET strategy, based on using directly observed, high-efficacy intravenously ...

Early High Efficacy Treatment in Multiple Sclerosis Is the Best ...

Patients with a medium or high risk of disease activity were significantly more likely to achieve NEDA on a high efficacy therapy as a first ...

The Argument for High-Efficacy Early Treatment for Pediatric-Onset ...

Despite having more active disease, current treatment guidelines for patients with POMS endorse the off-label use of lower-efficacy disease- ...

Early and unrestricted access to high-efficacy disease-modifying ...

... high-efficacy disease-modifying therapy ... Stankiewicz JM, Weiner HL (2020) An argument for broad use of high efficacy treatments in early ...

Multiple sclerosis patients' understanding and preferences for risks ...

One such benefit is improvement in treatment adherence, as patients with accurate understanding of treatment risk-benefit profiles are less likely to ...

Benefits of early highly effective versus escalation treatment ...

An argument for broad use of high efficacy treatments in early multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2020; 7(1): e636. Go to ...

The Multiple Sclerosis Controversy: Is It Escalation or Induction High ...

Stankiewicz JM, Weiner HL. An argument for broad use of high efficacy treatments in early multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2019;7(1). pii: ...

Treatment initiation on low-efficacy versus high-efficacy therapies in ...

Stankiewicz, J.M. ∙ Weiner, H.L.. An argument for broad use of high efficacy treatments in early multiple sclerosis. Neurol. Neuroimmunol. Neuroinflamm. 2020 ...

Relapsing-Remitting Multiple Sclerosis and High-efficacy Therapies

Drugs that reduce ARR relative to first-generation therapies are labeled high-efficacy agents, but protection against neurodegeneration ...

Initial high-efficacy disease-modifying therapy in multiple sclerosis

This study provides Class III evidence that for patients with MS, starting heDMT lowers the risk of EDSS worsening and relapses compared to starting meDMT.

Benefits of early treatment with natalizumab: a real-world study

A similar controversy was seen with rheumatoid arthritis, with observational studies suggesting the benefits of early high-efficacy therapy (Lard et al., 2002; ...

[PDF] Early and unrestricted access to high-efficacy disease ...

An argument for broad use of high efficacy treatments in early multiple sclerosis · Medicine. Neurology: Neuroimmunology & Neuroinflammation · 2019.

Escalation vs. Early Intense Therapy in Multiple Sclerosis - MDPI

On the other hand, “early intense therapy” strategy refers to starting treatment with drugs of higher efficacy from the beginning, despite having a less ...

Benefits of early highly effective versus escalation treatment ...

Stankiewicz JM, Weiner HL. An argument for broad use of high efficacy treatments in early multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2020; 7(1): ...

Early High Efficacy Treatment in Multiple Sclerosis Is the ... - Frontiers

The current European and American treatment guidelines only advise the use of high efficacy drugs for highly active disease. (6, 7). Time to ...

Highly Effective Therapies as First-Line Treatment for Pediatric ...

In this cohort, inefficacy and intolerance were the main reasons for discontinuation, suggesting suboptimal strategies. As expected, disease ...

Change from platform to high efficacy disease-modifying treatment ...

Thus, early initiation of high efficacy therapy appears to be the best therapeutic strategy for most patients, and thanks to the change in ...

Escalating to medium‐ versus high‐efficacy disease modifying ...

These results imply that patients initially treated with an escalation approach (i.e., first treatment with a low-efficacy DMT) could benefit ...