• An orally active formulation of angiotensin|🔍
• An orally active entry inhibitor of influenza A viruses protects mice ...🔍
• Discovery of an orally active benzoxaborole prodrug effective in the ...🔍
• An Orally Active Bradykinin B1 Receptor Antagonist Engineered as ...🔍
• Discovery of an orally active small|molecule irreversible inhibitor of ...🔍
• Orally Active Peptides🔍
• Discovery of an orally active nitrothiophene|based antitrypanosomal ...🔍
• Discovery of BPR1R024🔍

An orally active formulation of angiotensin-(1-7) produces ... - PubMed

These results show for the first time that the oral formulation Ang-(1-7)-CyD has biological activity and produces a Mas-dependent antithrombotic effect.

An orally active entry inhibitor of influenza A viruses protects mice ...

Small-molecule IAV entry inhibitor, ING-1466, binds to hemagglutinin (HA) and blocks HA-mediated viral infection. Here, we show that this ...

Discovery of an orally active benzoxaborole prodrug effective in the ...

Here we describe the discovery of a series of benzoxaborole compounds with nanomolar activity against extra- and intracellular stages of T. cruzi.

An orally active entry inhibitor of influenza A viruses protects mice ...

When administered orally it elicits a therapeutic effect in mice, even after the well-established infection. Moreover, the combination of ING- ...

An Orally Active Bradykinin B1 Receptor Antagonist Engineered as ...

Abstract ... An orally active and metabolically stable peptide TIBA was successfully engineered as a chimera by fusing an analgesic bradykinin ...

Discovery of an orally active small-molecule irreversible inhibitor of ...

We report a class of propynoic acid carbamoyl methyl amides (PACMAs) that are active against a panel of human ovarian cancer cell lines.

Orally Active Peptides: Is There a Magic Bullet? - Wiley Online Library

We explain why no simple and straightforward strategy (ie a “magic bullet”) exists for the design of an orally active peptide with a druglike biological ...

Discovery of an orally active nitrothiophene-based antitrypanosomal ...

We report the antitrypanosomal activity of a series of potent compounds. A subset of molecules in the series are highly selective for trypanosomes and are ...

Discovery of BPR1R024, an Orally Active and Selective CSF1R ...

The biological data demonstrate that the 7-aminoquinazolines show the increased CSF1R kinase selectivity over AURB and VEGFR2, compared to the ...

Discovery of an orally active subtype-selective HDAC inhibitor ...

We discuss the evidence supporting chidamide as a durable epigenetic modulator that allows cellular reprogramming with little cytotoxicity in cancer treatments.

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of ...

We have discovered and optimized a novel class of small-molecule boron-containing compounds, benzoxaboroles, to identify SCYX-7158 as an effective, safe and ...

The Engineering of an Orally Active Conotoxin for the Treatment of ...

Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the ...

Orally Active Compound Library - MedchemExpress.com

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of ...

orally active drug: Topics by Science.gov

In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and ...

Rifampicin: A New Orally Active Rifamycin - Karger Publishers

Rifampicin: A New Orally Active Rifamycin. Subject Area: Further Areas , Oncology , Pharmacology. N. Maggi; N. Maggi Research Laboratories, Lepetit SpA, Milan ...

Oral administration - Wikipedia

Oral administration is a route of administration whereby a substance is taken through the mouth, swallowed, and then processed via the digestive system.

Beneficial effects of physical exercise and an orally active mGluR2/3 ...

Our study points to BCI-838 as a safe and orally active compound capable of mimicking the beneficial effect of PE on AHN and recognition memory.

Identification of an orally active small-molecule PTHR1 agonist for ...

Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), ...

Nirmatrelvir, an orally active Mpro inhibitor, is a potent ... - bioRxiv

Nirmatrelvir (PF-07321332) is a specific inhibitor of coronavirus main protease (Mpro, also referred to as 3CLpro), with potent antiviral ...

Antitumor activity of MLN8054, an orally active small-molecule ...

MLN8054 possesses broad antitumor activity, inhibiting the in vitro proliferation of a number of cultured human tumor cell lines and inhibiting the growth of ...