An overview of the non|canonical inflammasome

An overview of the non-canonical inflammasome - PubMed

Inflammasomes are large cytosolic multiprotein complexes assembled in response to infection and cellular stress, and are crucial for the ...

An overview of the non-canonical inflammasome - ScienceDirect.com

Here we discuss the mechanism of non-canonical inflammasome activation, mechanisms regulating its activity and its contribution to health and disease.

An overview of the non-canonical inflammasome. - Semantic Scholar

Semantic Scholar extracted view of "An overview of the non-canonical inflammasome." by K. Downs et al.

The non-canonical inflammasome activators Caspase-4 and ...

The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and ...

Review The noncanonical inflammasome in health and disease

This review will summarize the recent advances on the noncanonical inflammasome, its mechanism of activation, key cellular regulators and role in health and ...

An overview of the non-canonical inflammasome - ResearchGate

Inflammasomes are large cytosolic multiprotein complexes assembled in response to infection and cellular stress, and are crucial for the activation of ...

Non-Canonical Inflammasome Pathway: The Role of Cell Death and ...

It has been demonstrated that inflammasomes are essential for the host's ability to fight off infection [1]. However, the development of immunopathology, ...

Non-Canonical Inflammasome Pathway: The Role of Cell Death and ...

The non-canonical inflammasome pathway is induced upon detecting cytosolic lipopolysaccharide (LPS) by NLRP3 inflammasome in Gram-negative bacteria.

The noncanonical inflammasome in health and disease - SciOpen

This review will summarize the recent advances on the noncanonical inflammasome, its mechanism of activation, key cellular regulators and role in health and ...

Canonical and Non-canonical Inflammasome Activation by Outer ...

Inflammasomes are multiprotein complexes that assemble in the cytosol of different epithelial and immune cells, particularly in macrophages, and ...

An overview of the non-canonical inflammasome - OUCI

Aachoui, Canonical inflammasomes drive IFN-gamma to prime caspase-11 in defense against a cytosol-invasive bacterium, Cell Host Microbe, № 18, с. · Aachoui, ...

Non-canonical inflammasome activation targets caspase-11 - Nature

It has long been presumed that caspase-11 is pro-inflammatory because of its homology to caspase-1, but its actual role has been enigmatic.

Roles of the Caspase-11 Non-Canonical Inflammasome in ... - MDPI

Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical ...

Caspase‐11 non‐canonical inflammasome: a critical sensor of ...

Caspase-11 non-canonical inflammasome recognizes intracellular lipopolysaccharide and activates caspase-1 ... Summary. Inflammatory responses ...

Inflammasome activation and regulation: toward a better ... - Nature

Upon activation, assembly of inflammasomes requires interactions between the inflammasome sensor and inflammatory caspase-1 or noncanonical ...

Novel perspectives on non-canonical inflammasome activation | ITT

In this review, we bring together the latest data on the roles of caspase-11 and the mechanisms underlying caspase-11-mediated activation of the ...

Inflammasome - Wikipedia

In mice, the non-canonical inflammasome is activated by direct sensing of cytosolic bacterial lipopolysaccharide (LPS) by caspase-11, which subsequently induces ...

SnapShot: The Noncanonical Inflammasome

Effector Functions of the Non-canonical Inflammasome Pathway. Different from caspase 1, caspase 11/4/5 do not process interleukins but only ...

Activation of the Non-canonical Inflammasome in Mouse and ...

The non-canonical inflammasome is a signaling platform that allows for the detection of cytoplasmic lipopolysaccharides (LPS) in immune and ...

Functional crosstalk between non‐canonical caspase‐11 and ...

The role of the NLRP3 inflammasome in inflammatory responses has been extensively investigated; however, the caspase-11 inflammasome has been ...